Table 1.

Assumptions on the resources needed to intrathecally administer an HD DMT per patient, based on the GENERATION HD1 protocol

Resource	Assumptions based on the GENERATION HD1 protocol (time calculated as FTE)
Proceduralist x1	60 minutes of total proceduralist time needed per procedure:
	•15 minutes –patient preparation
	•40 minutes –collection of CSF samples for analysis
	•5 minutes –IT bolus injection
Nurse x2	155 minutes of total nurse time needed per procedure:
	•10 minutes –patient check-in and education
	•10 minutes –facility preparation
	•15 minutes –patient preparation
	•40 minutes –CSF collection (2 nurses, 40 minutes per nurse)
	•5 minutes –IT bolus injection (2 nurses, 5 minutes per nurse)
	•30 minutes –patient mobilisation and monitoring
Facilities to perform the procedure x1	70 minutes of chair/bed occupancy needed per procedure:
	•10 minutes –facility preparation
	•15 minutes –patient preparation
	•40 minutes –CSF collection
	•5 minutes –IT bolus injection

CSF, cerebrospinal fluid; DMT, disease-modifying therapy; FTE, full-time equivalent; HD, Huntington’s disease; IT, intrathecal.