. 2021 Jun 1;81(3):1211–1229. doi: 10.3233/JAD-210137

Table 3.

Determinants of global cognition at the end of study: LnMMSE_2, placebo group^*

Variable	Pearson correlation		Multiple regression^#
(n = 82–112)
			Model 1		Model 2		Model 3		Model 4		Model 5		Model 6
	β	p	β	p	β	p	β	p	β	p	β	p	β	p
LntHcy_1	–0.28	0.003	–0.32	0.017	–0.29	0.030	–0.32	0.023	–0.31	0.024	–0.27	0.050	–0.29	0.037
LnPOase_1	–0.06	0.526							–0.28	0.246	–0.04	0.725
LnPhAcase_1	–0.11	0.286	–0.24	0.034	–0.23	0.033
PON1-Q192R	–0.01	0.964	–0.02	0.854			0.06	0.624	0.30	0.211
LnTG_1	–0.08	0.387	–0.22	0.044	–0.20	0.058	–0.20	0.080	–0.19	0.099	–0.20	0.071	–0.19	0.084
LnFe_1	0.05	0.650	0.24	0.031	0.23	0.030	0.28	0.014	0.26	0.023	0.29	0.010	0.27	0.013
LnAtrophy_rate	–0.31	0.006	–0.27	0.029	–0.25	0.038	–0.24	0.057	–0.25	0.045	–0.24	0.062	0.33	0.002
LnMMSE_1	0.34	0.000	0.26	0.017	0.29	0.005	0.32	0.004	0.30	0.006	0.43	0.000	0.33	0.002
Age	–0.28	0.003	–0.24	0.056	–0.26	0.034	–0.24	0.063	–0.23	0.071	–0.27	0.039	–0.26	–0.041
			F = 5.63,		F = 5.63,		F = 4.86,		F = 4.57,		F = 4.73,		F = 5.21,
			p = 0.000,		p = 0.000,		p = 0.000,		p = 0.000,		p = 0.000,		p = 0.000,
			Adjusted		Adjusted		Adjusted		Adjusted		Adjusted		Adjusted
			R² = 0.43		R² = 0.43		R² = 0.39		R² = 0.39		R² = 0.38;		R² = 0.38

^*Ln, natural logarithm; PhAcase, phenylacetate hydrolase; POase, paraoxonase; TG, triglyceride; _1, baseline; _2, end of study. ^# Adjusted for sex, LnAnti-N-Hcy_1, and BDNF V66M genotype.