. 2021 Jun 1;81(3):1211–1229. doi: 10.3233/JAD-210137

Table 7.

Determinants of attention/processing speed at the end of study: LnTrail_making_A_2, placebo group^*

Variable	Pearson correlation		Multiple regression^#
(n = 78–110)
			Model 1		Model 2		Model 3		Model 4		Model 5		Model 6
	β	p	β	p	β	p	β	p	β	p	β	p	β	p
LntHcy-_1	0.38	0.000	0.32	0.008	0.32	0.008	0.31	0.014	0.31	0.014	0.26	0.028
LnPOase_1	0.16	0.120							0.16	0.453	0.14	0.148
LnPhAcase_1	0.14	0.163	0.24	0.015	0.19	0.055
*PON1-Q192R*	0.08	0.434	0.19	0.049			0.13	0.193	–0.02	0.295
LnAnti-N-Hcy_1	–0.02	0.877	0.24	0.025	0.27	0.011	0.26	0.020	0.24	0.028	0.25	0.025	0.28	0.011
LnAtrophy_rate	0.34	0.002	0.30	0.007	0.30	0.007	0.28	0.013	0.29	0.013	0.29	0.010	0.29	0.011
LnTrail_making_A _1	0.52	0.000	0.32	0.001	0.32	0.001	0.29	0.003	0.29	0.003	0.28	0.004	0.30	0.003
Age	0.37	0.000	0.31	0.005	0.31	0.005	0.32	0.005	0.32	0.006	0.32	0.006	0.32	0.005
			F = 6.70,		F = 6.53,		F = 6.05,		F = 5.61,		F = 6.20,		F = 6.59,
			p = 0.000,		p = 0.000,		p = 0.000,		p = 0.000,		p = 0.000,		p = 0.000,
			Adjusted		Adjusted		Adjusted		Adjusted		Adjusted		Adjusted
			R² = 0.57		R² = 0.54		R² = 0.52		R² = 0.51		R² = 0.52;		R² = 0.52

^*Ln, natural logarithm; PhAcase, phenylacetate hydrolase; POase, paraoxonase; _1, baseline; _2, end of study. ^#Adjusted for sex, LnFA_1, LnTG_1, COMT V158M and DHFR 19bpins genotypes.