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. 2021 Jun 1;81(3):1211–1229. doi: 10.3233/JAD-210137

Table 8.

Determinants of attention/processing speed at the end of study: LnSDMT_2, placebo group

Variable Pearson correlation Multiple regression#
(n = 78–109)
Model 1 Model 2 Model 3 Model 4 Model 5 Model 6
β p β p β p β p β p β p β p
LntHcy-_1 –0.31 0.001 –0.20 0.013 –0.19 0.013 –0.19 0.025 –0.19 0.019 –0.19 0.022 –0.18 0.026
LnPOase_1 –0.17 0.107 –0.33 0.028 –0.06 0.336
LnPhAcase_1 –0.14 0.162 –0.18 0.008 –0.16 0.011
PON1-Q192R –0.04 0.702 –0.06 0.417 0.00 0.963 0.29 0.047
LnFA_1 –0.14 0.157 –0.20 0.020 –0.20 0.017 –0.21 0.020 –0.19 0.032 –0.24 0.005 –0.24 0.006
LnAnti-N–Hcy_1 –0.01 0.912 –0.15 0.041 –0.15 0.027 –0.17 0.025 –0.14 0.047 –0.15 0.036 –0.17 0.017
LnAtrophy_rate –0.35 0.002 –0.24 0.001 –0.24 0.001 –0.22 0.005 –0.23 0.002 –0.21 0.005 –0.22 0.004
LnSDMT _1 0.80 0.000 0.65 0.000 0.67 0.000 0.67 0.000 0.65 0.000 0.67 0.000 0.68 0.000
Age –0.35 0.000
F = 23.20, F = 27.39, F = 22.18, F = 22.04, F = 24.03, F = 27.23,
p = 0.000, p = 0.000, p = 0.000, p = 0.000, p = 0.000, p = 0.000,
Adjusted Adjusted Adjusted Adjusted Adjusted Adjusted
R2 = 0.78 R2 = 0.79 R2 = 0.76 R2 = 0.78 R2 = 0.77; R2 = 0.77

*Ln, natural logarithm; PhAcase, phenylacetate hydrolase; POase, paraoxonase; _1, baseline; _2, end of study. # Adjusted for sex, and LnTG_1.