Table 10.
Variable | Global cognition | Episodic memory | Attention/processing speed | |||||||||||
(n = 82–112) | ||||||||||||||
LnMMSE_21 | LnTICSm_22 | LnHVLT-TR_23 | LnHVLT-DR_24 | LnTrail_Making_A _25 | LnSDMT_26 | LnSDMT_27 | ||||||||
β | p | β | p | β | p | β | p | β | p | β | p | β | p | |
LntHcy-_1 | –0.03 | 0.798 | –0.02 | 0.859 | –0.02 | 0.873 | –0.21 | 0.024 | –0.18 | 0.062 | ||||
LnPOase_1 | 0.38 | 0.094 | ||||||||||||
LnPhAcase_1 | 0.09 | 0.569 | 0.24 | 0.056 | –0.02 | 0.843 | 0.14 | 0.306 | 0.16 | 0.288 | 0.13 | 0.184 | ||
PON1-Q192R | 0.05 | 0.686 | –0.31 | 0.160 | ||||||||||
LnTG_1 | 0.03 | 0.792 | 0.23 | 0.046 | 0.20 | 0.079 | ||||||||
LnFA_1 | 0.06 | 0.632 | 0.01 | 0.952 | ||||||||||
LnFe_1 | 0.17 | 0.201 | ||||||||||||
LnAnti-N-Hcy_1 | 0.00 | 0.981 | 0.06 | 0.632 | –0.18 | 0.051 | –0.14 | 0.143 | ||||||
BDNF V66M | –0.01 | 0.916 | –0.03 | 0.826 | ||||||||||
LnAtrophy_rate | –0.16 | 0.182 | –0.13 | 0.259 | –0.08 | 0.479 | 0.03 | 0.826 | 0.12 | 0.318 | –0.09 | 0.308 | –0.07 | 0.442 |
LnMMSE_1 | 0.52 | 0.000 | ||||||||||||
LnTICS-m_1 | 0.38 | 0.002 | ||||||||||||
LnHVLT-TR_1 | 0.63 | 0.000 | ||||||||||||
LnHVLT-DR_1 | 0.47 | 0.001 | ||||||||||||
LnTrail Making_1 | 0.62 | 0.000 | ||||||||||||
LnSDMT_1 | 0.65 | 0.000 | 0.66 | 0.000 | ||||||||||
F = 2.44, | F = 4.44, | F = 6.37, | F = 2.64, | F = 2.81, | F = 11.03, | F = 9.26, | ||||||||
p = 0.000, | p = 0.000, | p = 0.000, | p = 0.000, | p = 0.000, | p = 0.000, | |||||||||
Adjusted | Adjusted | Adjusted | Adjusted | Adjusted | Adjusted | |||||||||
R2 = 0.20 | R2 = 0.28 | R2 = 0.38 | R2 = 0.20 | R2 = 0.30; | R2 = 0.61 | R2 = 0.60 |
*Ln, natural logarithm; PhAcase, phenylacetate hydrolase; POase, paraoxonase; TG, triglycerides; FA, fatty acids; _1, baseline; _2, end of study. 1-7Adjusted for sex, age. Additional adjustment for: 1,4 Anti-N-Hcy, tHcy_1; 1BDNF V66M genotype; 3 Creatinine, TCN 776CG genotype; 4 APOE genotype; 5 Fe_1, FA_1, TG_1, COMT V158M and DHFR 19bpins genotypes.