. 2021 Jun 1;81(3):1211–1229. doi: 10.3233/JAD-210137

Table 10.

Determinants of cognition at the end of study –B vitamin group^*

Variable	Global cognition				Episodic memory				Attention/processing speed
(n = 82–112)
	LnMMSE_2¹		LnTICSm_2²		LnHVLT-TR_2³		LnHVLT-DR_2⁴		LnTrail_Making_A _2⁵		LnSDMT_2⁶		LnSDMT_2⁷
	β	p	β	p	β	p	β	p	β	p	β	p	β	p
LntHcy-_1	–0.03	0.798	–0.02	0.859					–0.02	0.873	–0.21	0.024	–0.18	0.062
LnPOase_1													0.38	0.094
LnPhAcase_1	0.09	0.569	0.24	0.056	–0.02	0.843	0.14	0.306	0.16	0.288	0.13	0.184
PON1-Q192R									0.05	0.686			–0.31	0.160
LnTG_1	0.03	0.792									0.23	0.046	0.20	0.079
LnFA_1											0.06	0.632	0.01	0.952
LnFe_1	0.17	0.201
LnAnti-N-Hcy_1			0.00	0.981					0.06	0.632	–0.18	0.051	–0.14	0.143
BDNF V66M					–0.01	0.916	–0.03	0.826
LnAtrophy_rate	–0.16	0.182	–0.13	0.259	–0.08	0.479	0.03	0.826	0.12	0.318	–0.09	0.308	–0.07	0.442
LnMMSE_1	0.52	0.000
LnTICS-m_1			0.38	0.002
LnHVLT-TR_1					0.63	0.000
LnHVLT-DR_1							0.47	0.001
LnTrail Making_1									0.62	0.000
LnSDMT_1											0.65	0.000	0.66	0.000
	F = 2.44,		F = 4.44,		F = 6.37,		F = 2.64,		F = 2.81,		F = 11.03,		F = 9.26,
	p = 0.000,		p = 0.000,		p = 0.000,		p = 0.000,		p = 0.000,		p = 0.000,
	Adjusted		Adjusted		Adjusted		Adjusted		Adjusted		Adjusted
	R² = 0.20		R² = 0.28		R² = 0.38		R² = 0.20		R² = 0.30;		R² = 0.61		R² = 0.60

^*Ln, natural logarithm; PhAcase, phenylacetate hydrolase; POase, paraoxonase; TG, triglycerides; FA, fatty acids; _1, baseline; _2, end of study. ^1-7Adjusted for sex, age. Additional adjustment for: ^1,4 Anti-N-Hcy, tHcy_1; ¹BDNF V66M genotype; ³ Creatinine, TCN 776CG genotype; ⁴ APOE genotype; ⁵ Fe_1, FA_1, TG_1, COMT V158M and DHFR 19bpins genotypes.