Fig. 4.

RRY attenuates spatial memories deficit of the APP/PS1 transgenic mice in MWM. A) In the first day of acquisition test (visible platform), no significant difference of escape latencies among groups was observed (p > 0.05). During the 2nd day and the 5th day (hidden platform), the mice infuse with RRY showed a shorter latency compared to groups Tg Vehicle and Tg Ctrl (^***p < 0.001). In the reversal test, a significant disparity was shown in the 7th and the 8th day (^***p < 0.001). B-D) In the probe test on the 6^th day, the mice of group RRY pass the platform area more frequently (B) (^***p < 0.001), had longer path length (C) (p < 0.01), and stay longer on the platform (D) (^***p < 0.001) in the target quadrant than group vehicle and group Tg Ctrl. n = 7.