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. 2021 Jul 7;9:661317. doi: 10.3389/fcell.2021.661317

FIGURE 5.

FIGURE 5

Exosomal miR-19b-3p derived from ADSCs inhibited ferroptosis in ICH mice. Mice were randomly divided into 2 groups: ICH+ADSCs-MNC Exos and ICH+ADSCs-19bM-Exos. (A) qRT-PCR analysis of miR-19b-3p level in the plasma at 48 h after ICH in mice. (B) Neurological function at 48 h after ICH in mice was evaluated by mNSS. (C) Western blot analysis of IRP2, FPN, and TfR1 in the brain at 48 h after ICH in mice. (D) The iron deposition in the mouse brain at 48 h was determined by Perls’ Prussian blue staining (scale bar: 10 μm). (E) The contents of iron, MDA, GSH, and GPX4 in the brain at 48 h after ICH in mice. N = 10 in each group. *P < 0.05, **P < 0.01, vs. ICH+ADSCs-MNC Exos.