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. Author manuscript; available in PMC: 2022 Jan 14.
Published in final edited form as: J Med Chem. 2021 Jan 4;64(1):662–676. doi: 10.1021/acs.jmedchem.0c01671

Figure 1.

Figure 1.

(A) Positive charge on the phosphorus atom of a TPP+ conjugate is diffused through the aryl rings because of the resonance of pi-electrons. (B) Schematic representation of membrane potential-driven uptake of TPP+ conjugates by mitochondria inside intact cells.