Table 1.
Characteristics of AIS patients According to Eosinophil Changes After Intravenous Thrombolysis.
| Variable | Total (n = 623) | Increase or no change (n = 229) | 0< decrease ≤25% (n = 88) | 25%< decrease ≤50% (n = 102) | 50%< decrease ≤75% (n = 66) | 75%< decrease ≤100% (n = 138) | p value |
|---|---|---|---|---|---|---|---|
| Demographic data | |||||||
| Age (years) | 67.36 ± 12.84 | 66.28 ± 12.54 | 66.53 ± 12.44 | 66.17 ± 12.56 | 68.18 ± 12.44 | 70.16 ± 13.69 | 0.045 |
| Sex (male, n.%) | 403 (64.69) | 157 (68.56) | 63 (71.59) | 68 (66.67) | 36 (54.54) | 79 (57.25) | 0.043 |
| Risk factors | |||||||
| Current smoking (n.%) | 166 (26.65) | 65 (28.38) | 33 (37.50) | 30 (29.41) | 11 (16.67) | 27 (19.57) | 0.011 |
| Hypertension (n.%) | 376 (60.35) | 139 (60.70) | 59 (67.05) | 59 (57.84) | 40 (60.61) | 79 (57.25) | 0.647 |
| Diabetes (n.%) | 113 (18.14) | 43 (18.78) | 25 (28.41) | 19 (18.63) | 12 (18.18) | 14 (10.14) | 0.015 |
| Atrial fibrillation (n.%) | 87 (13.96) | 20 (8.73) | 10 (11.37) | 15 (14.71) | 16 (24.24) | 26 (18.84) | 0.006 |
| Previous stroke (n.%) | 67 (10.75) | 28 (12.23) | 6 (6.82) | 9 (8.82) | 7 (10.61) | 17 (12.32) | 0.611 |
| Laboratory findings | |||||||
| Total cholesterol (mmol/L) | 4.83 ± 1.13 | 4.81 ± 1.11 | 4.83 ± 1.26 | 5.09 ± 1.19 | 4.63 ± 1.00 | 4.73 ± 1.05 | 0.072 |
| Triglycerides (mmol/L) | 1.59 ± 1.22 | 1.74 ± 1.30 | 1.68 ± 0.90 | 1.57 ± 0.82 | 1.39 ± 0.94 | 1.37 ± 1.55 | 0.039 |
| HDL cholesterol (mmol/L) | 1.10 ± 0.26 | 1.06 ± 0.24 | 1.05 ± 0.27 | 1.14 ± 0.27 | 1.15 ± 0.27 | 1.15 ± 0.26 | 0.001 |
| LDL cholesterol (mmol/L) | 2.92 ± 0.90 | 2.89 ± 0.83 | 2.97 ± 1.01 | 3.13 ± 0.97 | 2.77 ± 0.90 | 2.85 ± 0.85 | 0.069 |
| HbA1c values (%) | 6.52 ± 1.41 | 6.46 ± 1.32 | 6.56 ± 1.36 | 6.70 ± 1.53 | 6.48 ± 1.66 | 6.45 ± 1.36 | 0.683 |
| NLR (admission) | 2.20 (1.48–3.44) | 2.74 (1.74–4.33) | 1.81 (1.36–2.66) | 2.03 (1.40–3.04) | 2.14 (1.28–3.17) | 1.95 (1.37–2.34) | <0.001 |
| NLR (24 h) | 3.32 (2.30–5.00) | 2.61 (1.95–3.50) | 2.64 (2.05–3.63) | 3.00 (2.41–3.92) | 4.10 (3.10–5.80) | 6.48 (4.83–9.72) | <0.001 |
| NLR (percent changes, %) | 42 (−5–+126) | 0 (−36–+40) | 37 (−11–+73) | 40 (5–95) | 94 (29–200) | 231 (121–412) | <0.001 |
| Blood pressure | |||||||
| Systolic blood pressure (mmHg) | 159.41 ± 24.78 | 157.50 ± 24.10 | 154.67 ± 21.01 | 162.20 ± 23.06 | 159.00 ± 30.16 | 163.86 ± 26.21 | 0.053 |
| Diastolic blood pressure (mmHg) | 89.55 ± 15.18 | 88.87 ± 14.39 | 87.99 ± 13.88 | 92.24 ± 17.46 | 87.43 ± 16.43 | 90.49 ± 14.77 | 0.198 |
| Clinical characteristics | |||||||
| Onset to treatment (min) | 158 (122-204) | 173 (130–211) | 141 (104–188) | 152 (120–209) | 150 (113–197) | 152 (128–199) | 0.010 |
| Premorbid mRS 0–1, n (%) | 596 (95.67) | 221 (96.51) | 86 (97.73) | 99 (97.06) | 59 (89.39) | 131 (94.93) | 0.132 |
| Admission NIHSS scores | 6 (4–10) | 5 (4–8) | 5 (4–8) | 6 (3–9) | 7 (5–12) | 10 (6–16) | <0.001 |
| 24 h-NIHSS scores | 4 (2–8) | 4 (2–5) | 3 (2–7) | 4 (2–8) | 6 (4–11) | 8 (4–14) | <0.001 |
| 7 d-NIHSS scores | 3 (1–6) | 2 (1–4) | 2 (0–4) | 3 (1–7) | 4 (1–10) | 5 (2–12) | <0.001 |
| TOAST subtypes, n (%) | <0.001 | ||||||
| Cardioembolism | 187 (30.02) | 48 (20.96) | 22 (25.00) | 25 (24.51) | 26 (39.39) | 66 (47.83) | |
| Large artery atherosclerosis | 262 (42.05) | 105 (45.85) | 37 (30.68) | 43 (42.15) | 27 (40.91) | 50 (36.23) | |
| Small artery occlusion | 110 (17.66) | 48 (20.96) | 22 (25.00) | 22 (21.57) | 9 (13.64) | 9 (6.52) | |
| Other/undetermined | 64 (10.27) | 28 (12.23) | 7 (19.32) | 12 (11.76) | 4 (6.06) | 13 (9.42) |
HbA1c, glycated hemoglobin; NLR, neutrophil-to-lymphocyte ratio; mRS, modified Rankin Scale; NIHSS, National Institute of Health Stroke Scale.