. Author manuscript; available in PMC: 2021 Jul 21.

Published in final edited form as: Inorg Chem. 2020 Jul 28;59(16):11715–11727. doi: 10.1021/acs.inorgchem.0c01629

Table 2.

Results from radiolabeling DFO and DFO2 with zirconium-89.^*

Complex	Chelator (nmol)	[⁸⁹Zr]Zr-oxalate (μCi) / (MBq)	RCY 60 min (%)	SA (mCi•μmol⁻¹) / (MBq•μmol⁻¹)	logD_{PBS pH 7.4}
[⁸⁹Zr]Zr- (DFO2)	500	459 / 17.0	99	0.9 / 33.6	−0.71 ± 01
	50	282 / 10.4	99	5.6 / 207
	5	290 / 10.7	7.4	4.3 / 159
	0.5	283 / 10.5	1	~
[⁸⁹Zr]Zr-(DFO)	500	273 / 10.1	99	0.5 / 20.0	−2.70 ± 06
	50	276 / 10.2	99	5.5 / 202
	5	269 / 10.0	2.3	~
	0.5	282 / 10.4	1.4	~

At chelator concentrations of 500−0.5 nmol, radiochemical yields (RCY) determined via radio-iTLC (n=3), and logD octanol-buffer partition coefficient values (phosphate buffered saline pH=7.4) (n=5).