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. 2021 Jul 7;12:678036. doi: 10.3389/fimmu.2021.678036

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Copyright © 2021 Gu, Upchurch, Horton, Wiest, Zurawski, Millard, Kane, Joo, Miller and Oh

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anti-hDectin-1-Pam₃CSK₄ Conjugate Can Suppress Allergen-Specific IgE Response in Macaques In Vivo. (A) Anti-hDectin-1 mAb (clone 15E2) bound to CD11c⁺ DCs and CD14⁺ monocytes in macaque PBMCs. Representative FACS data of five animals is shown. (B) Scheme of the second in vivo test in NHP. Injection of HDM extract, bleeding, and treatment with anti-hDectin-1-Pam₃CSK₄ conjugate was performed as indicated. (C) Der p 1-specific IgE and total IgE in the serum of animals at indicated time points were measured by ELISA. Data in (C) are represented as mean ± SD. Significance was determined using two-way ANOVA with Tukey multiple comparisons test for (C). *p < 0.05 for the comparison between groups. ns, not significant.