Table 2.

Explained variance, MAF and reported effect size of the three SNPs associated with the plasma levels of protein DEFB119, as well as the corresponding true-positive rate and the estimated regression coefficients from standard LASSO and robust Huber-LASSO

Associated SNP	Explained variance	MAF	Reported effect size	Standard LASSO				Robust Huber-LASSO
				True-positive rate	Estimated coefficient			True-positive rate	Estimated coefficient
					Mean	95% CI			Mean	95% CI
No simulated outlier
rs9296004	0.055	0.082	0.606	0.970	0.253	0.233	0.273	0.970	0.281	0.253	0.309
rs11845244	0.027	0.354	0.241	0.850	0.094	0.082	0.106	0.850	0.103	0.087	0.118
rs12301299	0.018	0.163	0.254	0.960	0.127	0.114	0.139	0.840	0.095	0.082	0.109
Average genotype
Simulated protein residual = 5
rs9296004	0.055	0.082	0.606	0.930	0.229	0.208	0.250	0.960	0.279	0.251	0.308
rs11845244	0.027	0.354	0.241	0.790	0.078	0.066	0.091	0.840	0.100	0.085	0.116
rs12301299	0.018	0.163	0.254	0.940	0.122	0.109	0.135	0.830	0.096	0.082	0.110
Simulated protein residual = −5
rs9296004	0.055	0.082	0.606	0.950	0.247	0.226	0.269	0.950	0.287	0.258	0.317
rs11845244	0.027	0.354	0.241	0.860	0.095	0.082	0.108	0.860	0.107	0.091	0.123
rs12301299	0.018	0.163	0.254	0.960	0.121	0.108	0.134	0.870	0.096	0.083	0.109
Divergent genotype
Simulated protein residual = 5
rs9296004	0.055	0.082	0.606	0.960	0.230	0.21	0.251	0.960	0.281	0.253	0.310
rs11845244	0.027	0.354	0.241	0.810	0.090	0.078	0.103	0.840	0.104	0.088	0.120
rs12301299	0.018	0.163	0.254	0.950	0.120	0.107	0.133	0.860	0.097	0.084	0.111
Simulated protein residual = −5
rs9296004	0.055	0.082	0.606	0.960	0.247	0.225	0.269	0.950	0.288	0.259	0.316
rs11845244	0.027	0.354	0.241	0.800	0.082	0.070	0.095	0.850	0.103	0.088	0.119
rs12301299	0.018	0.163	0.254	0.970	0.126	0.113	0.138	0.880	0.097	0.084	0.110