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. 2020 Nov 5;22(4):bbaa264. doi: 10.1093/bib/bbaa264

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© The Author(s) 2020. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Mean proportion false discoveries of LRT and Wald statistics when using the asymptotic (black) and their corresponding bootstrap-based null distribution (blue) for testing versus or . We have also compared with the F-test statistic in limma-voom approach (green) and LRT and -test statistic in edgeR (red). Each panel corresponds to proportion false discoveries (top left), proportion discoveries (top right), proportion true discoveries (bottom left) and proportion true negative discoveries (bottom right).

Inline graphic — Mean proportion false discoveries of LRT and Wald statistics when using the asymptotic (black) and their corresponding bootstrap-based null distribution (blue) for testing versus or . We have also compared with the F-test statistic in limma-voom approach (green) and LRT and -test statistic in edgeR (red). Each panel corresponds to proportion false discoveries (top left), proportion discoveries (top right), proportion true discoveries (bottom left) and proportion true negative discoveries (bottom right).