Table 6.
Mean proportion true negative discoveries for LRT and Wald statistics from the Negative Binomial mixed model when using the asymptotic 
(‘LRT’ and ‘W’, respectively) and their corresponding bootsrap-based null distribution (“LRT-boot” and “W-boot”, respectively) for testing 
versus 
or 
. We have made comparisons with the 
-test statistic in limma-voom approach (“F-voom”) and LRT and 
-test statistic in edgeR (“LRT-edgeR” and “W-edgeR”, respectively)
|
LRT | LRT-edgeR | F-edgeR | W | LRT-boot | W-boot | F-voom |
|---|---|---|---|---|---|---|---|
| 0.5 | 0.483 | 0.500 | 0.500 | 0.474 | 0.490 | 0.490 | 0.498 |
| 1.5 | 0.484 | 0.305 | 0.333 | 0.474 | 0.492 | 0.493 | 0.078 |
| 2.0 | 0.483 | 0.308 | 0.332 | 0.472 | 0.493 | 0.494 | 0.026 |