Table.
Effects of increased activation/expression of Nox isoforms and mitochondria in the pathophysiology of hypertension
| Source | Consequence |
|---|---|
| Nox1 | ↓endothelial relaxation |
| ↑vascular remodeling | |
| ↑fibrosis | |
| ↑blood pressure | |
| Nox2 | ↑inflammation |
| ↑blood pressure | |
| ↑neuronal excitability | |
| ↑T cell proliferation | |
| Nox4 | ↑endothelial relaxation |
| ↓vascular remodeling | |
| ↓or no △ blood pressure oncoprotein renal dysfunction | |
| Nox5 (SMC) | ↑vasoconstriction |
| ↓endothelial relaxation no change in blood pressure in young mice hypertension with aging stroke accelerated vascular remodeling vascular calcification | |
| Nox5 (EC) | ↓endothelial relaxation |
| ↑systolic hypertension hypertensive retinopathy | |
| Mitochondria | ↓endothelial relaxation |
| ↑blood pressure |