Fig. 5. Proteolytic stability of bicycles and controls. (A) Stability of TSLs bicycles, disulfide constrained peptides, and linear peptides in the presence of Pronase™ and mouse serum for 5 hours at 37 °C. (B) Stability of peptides modified with TSLs, DBMB and PFS in the presence of Pronase™ for 5 hours at 37 °C. (C) Stability of 6a (disulfide-bonded), 6c (bicycled with TSL-1), and 6g (macro-cyclized with DBMB) in the presence of Pronase™.
