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Oral gavage with spermidine decrease lung tissue inflammation. Oral gavage with SPD decreases number of lung infiltrating cell as show in hematoxylin and eosin staining (A) and reconstitute impaired epithelial barrier (B) with increased expression of tight junction proteins (ZO‐1, cld‐4) as observed in immunofluorescence staining of lung tissue. SPM gavage did not exert the same effects on the lung tissue
