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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: IEEE Trans Med Imaging. 2021 Jun 1;40(6):1519–1530. doi: 10.1109/TMI.2021.3059726

TABLE V:

Post-hoc segmentation results on the 3 settings of the MS-SEG (lesion) dataset, the IXI MRI dataset (CSF: cerebrospinal fluid, GM: grey matter, WM: white matter), and the RETOUCH OCT dataset (IRF: intraretinal fluid, SRF: subretinal fluid, PED: pigment epithelial detachment). A→B indicates that the segmentation network is trained on domain A and tested on domain B. DC and IoU are Dice coefficient and Intersection over Union, respectively.

MS-SEG Results (Leave-one-subject-out cross-validation) SA → SV
 SA → PI
 SV → PI
DC (↑) IoU (↑) DC (↑) IoU (↑) DC (↑) IoU (↑)
Source Segmentor → Source Image 0.53 0.39 0.53 0.39 0.60 0.45
Target Segmentor → Target Image 0.60 0.45 0.57 0.41 0.57 0.41
Target Segmentor → Source Image 0.37 0.26 0.33 0.23 0.43 0.30
Target Segmentor → Harmonized Image (CycleGAN [8]) 0.42 0.30 0.31 0.19 0.26 0.18
Target Segmentor → Harmonized Image (S-CycleGAN [15]) 0.40 0.29 0.39 0.28 0.22 0.15
Target Segmentor → Harmonized Image (Ours) 0.50 0.38 0.49 0.35 0.51 0.37
RETOUCH OCT Results IRF
 SRF
 PED
DC (↑) IoU (↑) DC (↑) IoU (↑) DC (↑) IoU (↑)
Source Segmentor → Source Image 0.71 0.55 0.54 0.42 0.55 0.40
Target Segmentor → Target Image 0.72 0.56 0.70 0.54 0.11 0.06
Target Segmentor → Source Image 0.63 0.47 0.54 0.41 0.34 0.24
Target Segmentor → Harmonized Image (CycleGAN [8]) 0.58 0.41 0.57 0.43 0.51 0.40
Target Segmentor → Harmonized Image (S-CycleGAN [15]) 0.59 0.42 0.56 0.43 0.51 0.40
Target Segmentor → Harmonized Image (SemGAN [16]) 0.58 0.42 0.55 0.42 0.51 0.41
Target Segmentor → Harmonized Image (Proposed) 0.67 0.51 0.62 0.48 0.52 0.43
IXI MRI Results CSF
 GM
 WM
DC (↑) IoU (↑) DC (↑) IoU (↑) DC (↑) IoU (↑)
Source Segmentor → Source Image 0.90 0.83 0.91 0.83 0.88 0.81
Target Segmentor → Target Image 0.90 0.83 0.89 0.82 0.88 0.81
Target Segmentor → Source Image 0.85 0.75 0.82 0.72 0.77 0.70
Target Segmentor → Harmonized Image (CycleGAN [8]) 0.79 0.66 0.77 0.64 0.73 0.64
Target Segmentor → Harmonized Image (S-CycleGAN [15]) 0.61 0.46 0.64 0.48 0.71 0.61
Target Segmentor → Harmonized Image (SemGAN [16]) 0.80 0.68 0.76 0.64 0.72 0.64
Target Segmentor → Harmonized Image (Ours) 0.85 0.75 0.84 0.74 0.81 0.73