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. Author manuscript; available in PMC: 2021 Jul 21.
Published in final edited form as: ACS Chem Neurosci. 2019 Jan 31;10(4):2012–2021. doi: 10.1021/acschemneuro.8b00340

Figure 3.

Figure 3.

(A) Effects of administration of cumulative doses, in mg/kg, of R-MOD and each analog compound and cocaine on the rate of DA reuptake (clearance) at DA nerve terminals in the NAS. Baseline values: Cocaine, 1.61 ± 0.26 s−1 (n=6); R-MOD, 1.73 ± 0.21 s−1 (n=4); JJC8-016, 1.61 ± 0.22 s−1 (n=5); JJC8-088 2.17 ± 0.28 s−1 (n=4); JJC8-091 2.20 ± 0.08 s−1 (n=4). Baseline values were not found to be significantly different between groups or from vehicle treatments (SI Tables 1 and 2). (B) A relationship was found between the DAT affinity for the drugs tested (data from Cao et al, 2016 27) and the IC75, expressed as μmol/kg, measured in the present report. (B, inset) A similar relationship was not apparent between the maximal elicited DA peak and DAT affinity. Data represent mean ± SEM.