TABLE 2.
Correspondence between ARHGAP family gene expression and type of immune infiltration based on immuno-related markers in BCa.
| Description | Markers | ARHGAP5 | ARHGAP8 | ARHGAP11a | ARHGAP17 | ARHGAP24 | STARD13 | STARD8 | |||||||||||||||||||||||
| None | Purity | None | Purity | None | Purity | None | Purity | None | Purity | None | Purity | None | Purity | ||||||||||||||||||
| Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | Cor | P | ||||
| B cell | CD19 | –0.124 | 1.23E-02 | –0.069 | 1.86E-01 | –0.037 | 4.58E-01 | 0.022 | 6.69E-01 | –0.084 | 8.86E-02 | –0.046 | 3.82E-01 | 0.248 | 3.93E-07 | 0.168 | 1.25E-03 | 0.33 | 8.35E-12 | 0.178 | 6.12E-04 | 0.348 | 4.61E-13 | 0.183 | 4.14E-04 | 0.435 | 2.98E-20 | 0.274 | 8.94E-08 | ||
| CD79A | –0.074 | 1.38E-01 | –0.015 | 7.80E-01 | –0.054 | 2.75E-01 | 0.014 | 7.85E-01 | –0.13 | 8.81E-03 | –0.111 | 3.34E-02 | 0.188 | 1.38E-04 | 0.065 | 2.11E-01 | 0.354 | 1.84E-13 | 0.182 | 4.48E-04 | 0.39 | 3.11E-16 | 0.197 | 1.37E-04 | 0.471 | 6.22E-24 | 0.282 | 3.53E-08 | |||
| T cell(general) | CD2 | –0.07 | 8.81E+01 | 0.088 | 9.37E-02 | –0.193 | 8.92E-05 | –0.137 | 8.41E-03 | 0.022 | 6.52E-01 | 0.078 | 1.34E-01 | 0.248 | 3.77E-07 | 0.134 | 9.90E-03 | 0.338 | 2.46E-12 | 0.133 | 1.05E-02 | 0.391 | 8.84E-18 | 0.201 | 1.01E-04 | 0.485 | 0.00E+00 | 0.27 | 1.49E-07 | ||
| CD3D | –0.075 | 1.31E-01 | –0.013 | 8.05E-01 | –0.159 | 1.23E-03 | –0.098 | 5.92E-02 | –0.05 | 3.11E-01 | –0.033 | 5.31E-01 | 0.164 | 8.66E-04 | 0.031 | 5.59E-01 | 0.282 | 6.63E-09 | 0.087 | 9.68E-02 | 0.345 | 8.10E-13 | 0.156 | 2.71E-03 | 0.425 | 2.65E-19 | 0.206 | 7.04E-05 | |||
| CD3E | –0.005 | 9.20E-01 | 0.086 | 1.00E-01 | –0.196 | 6.45E-05 | –0.137 | 8.57E-03 | 0.007 | 8.86E-01 | 0.063 | 2.29E-01 | 0.245 | 5.30E-07 | 0.121 | 2.04E-02 | 0.365 | 2.87E-14 | 0.16 | 2.02E-03 | 0.418 | 0.00E+00 | 0.228 | 1.02E-05 | 0.499 | 0.00E+00 | 0.277 | 6.49E-08 | |||
| CD8+ T cell | CD8A | 0.011 | 8.21E-01 | 0.091 | 7.99E-02 | –0.174 | 4.05E-04 | –0.109 | 3.66E-02 | 0.15 | 2.35E-08 | 0.217 | 2.58E-05 | 0.303 | 4.25E-10 | 0.214 | 3.44E-05 | 0.315 | 7.70E-11 | 0.146 | 5.01E-03 | 0.354 | 2.33E-13 | 0.189 | 2.69E-04 | 0.442 | 0.00E+00 | 0.246 | 1.75E-06 | ||
| CD8B | 0.006 | 8.97E-01 | 0.057 | 2.74E-01 | –0.175 | 3.76E-04 | –0.118 | 2.41E-02 | 0.118 | 1.66E-02 | 0.161 | 1.92E-03 | 0.298 | 8.15E-10 | 0.234 | 5.55E-06 | 0.25 | 3.00E-07 | 0.133 | 1.05E-02 | 0.283 | 5.81E-09 | 0.152 | 3.45E-03 | 0.402 | 2.70E-17 | 0.275 | 8.55E-08 | |||
| Monocyte | CD86 | –0.008 | 8.73R-01 | 0.084 | 1.07E-01 | –0.302 | 4.79E-10 | –0.267 | 2.00E-07 | 0.136 | 5.96E-03 | 0.248 | 1.44E-06 | 0.344 | 8.73E-13 | 0.258 | 5.35E-07 | 0.505 | 8.54E-28 | 0.355 | 2.39E-12 | 0.477 | 0.00E+00 | 0.311 | 1.14E-09 | 0.562 | 0.00E+00 | 0.38 | 4.04E-14 | ||
| CSF1R | –0.011 | 8.21E-01 | 0.075 | 1.52E-01 | –0.265 | 5.22E-08 | –0.217 | 2.57E-05 | 0.039 | 4.30E-01 | 0.11 | 3.56E-02 | 0.364 | 3.34E-14 | 0.288 | 1.81E-08 | 0.533 | 2.77E-31 | 0.39 | 7.73E-15 | 0.583 | 0.00E+00 | 0.462 | 7.31E-21 | 0.669 | 0.00E+00 | 0.54 | 3.07E-29 | |||
| TAM | CCL2 | –0.097 | 5.04E-02 | –0.028 | 5.87E-01 | –0.067 | 1.76E-01 | 0.013 | 8.02E-01 | –0.009 | 8.63E-01 | 0.068 | 1.96E-01 | 0.381 | 1.43E-15 | 0.31 | 1.24E-09 | 0.473 | 3.89E-24 | 0.315 | 6.79E-10 | 0.526 | 0.00E+00 | 0.388 | 1.20E-14 | 0.601 | 0.00E+00 | 0.445 | 2.55E-19 | ||
| CD68 | 0.114 | 2.17E-02 | 0.17 | 1.07E-03 | –0.419 | 9.17E-19 | –0.392 | 6.25E-15 | 0.155 | 1.72E-03 | 0.218 | 2.41E-05 | 0.185 | 1.65E-04 | 0.074 | 1.55E-01 | 0.365 | 2.73E-14 | 0.232 | 7.16E-06 | 0.346 | 8.28E-13 | 0.197 | 1.39E-04 | 0.421 | 0.00E+00 | 0.258 | 5.19E-07 | |||
| IL10 | –0.064 | 1.97E+00 | –0.004 | 9.42E-01 | –0.137 | 5.43E-03 | –0.06 | 2.52E-01 | 0.087 | 7.82E-02 | 0.177 | 6.46E-04 | 0.362 | 4.70E-14 | 0.284 | 2.81E-08 | 0.533 | 2.61E-31 | 0.417 | 6.92E-17 | 0.569 | 2.16E-36 | 0.457 | 2.23E-20 | 0.617 | 4.48E-44 | 0.473 | 6.56E-22 | |||
| M1 Macrophage | INOS(NOS2) | 0.132 | 7.79E-03 | 0.159 | 2.16E-03 | –0.086 | 8.12E-02 | –0.043 | 4.06E-01 | 0.117 | 1.84E-02 | 0.151 | 3.64E-03 | 0.198 | 5.59E-05 | 0.181 | 4.77E-04 | 0.224 | 5.03E-06 | 0.176 | 6.94E-04 | 0.186 | 1.54E-04 | 0.157 | 2.58E-03 | 0.254 | 1.97E-07 | 0.195 | 1.74E-04 | ||
| IRF5 | –0.059 | 2.32E-01 | –0.08 | 1.26E-01 | 0.273 | 2.07E-08 | 0.264 | 2.72E-07 | –0.049 | 3.25E-01 | –0.051 | 3.25E-01 | –0.043 | 3.83E-01 | –0.053 | 3.14E-01 | –0.156 | 1.56E-03 | –0.165 | 1.47E-03 | –0.093 | 5.99E-02 | –0.103 | 4.73E-02 | –0.033 | 5.06E-01 | –0.041 | 4.33E-01 | |||
| COX2(PTGS2) | 0.258 | 1.37E-07 | 0.291 | 1.37E-08 | 0.077 | 1.21E-01 | 0.116 | 2.64E-02 | 0.033 | 5.09E-01 | 0.058 | 2.66E-01 | 0.098 | 4.76E-02 | 0.045 | 3.90E-01 | 0.207 | 2.40E-05 | 0.149 | 4.26E-03 | 0.351 | 4.11E+13 | 0.292 | 1.08E-08 | 0.125 | 1.15E-02 | 0.036 | 4.86E-01 | |||
| M2 Macrophage | CD163 | –0.068 | 1.70E-01 | 0.006 | 9.13E-01 | –0.229 | 2.95E-06 | –0.169 | 1.16E-03 | 0.12 | 1.55E-02 | 0.22 | 2.06E-05 | 0.385 | 7.07E-16 | 0.318 | 4.13E-10 | 0.525 | 2.51E-30 | 0.38 | 4.41E-14 | 0.549 | 0.00E+00 | 0.411 | 2.02E-16 | 0.677 | 0.00E+00 | 0.551 | 1.36E-30 | ||
| VSIG4 | –0.065 | 1.87E-01 | 0.007 | 9.00E-01 | –0.247 | 4.58E-07 | –0.198 | 1.32E-04 | 0.087 | 8.02E-02 | 0.175 | 7.49E-04 | 0.351 | 2.96E-13 | 0.28 | 4.65E-08 | 0.52 | 1.32E-29 | 0.374 | 1.12E-13 | 0.533 | 0.00E+00 | 0.396 | 2.99E-15 | 0.631 | 0.00E+00 | 0.487 | 2.65E-23 | |||
| MS4A4A | –0.072 | 1.46E-01 | 0.003 | 9.52R-01 | –0.258 | 1.31E-07 | –0.213 | 3.67E-05 | 0.098 | 4.81E-02 | 0.199 | 1.25E-04 | 0.345 | 7.74E-13 | 0.266 | 2.32E-07 | 0.545 | 5.85E-33 | 0.411 | 2.13E-16 | 0.546 | 0.00E+00 | 0.416 | 8.41E-17 | 0.677 | 0.00E+00 | 0.545 | 7.32E-30 | |||
| Neutrophils | CD66b(CEACAM8) | 0.102 | 3.93E-02 | 0.06 | 2.49E-01 | –0.047 | 3.41E-01 | –0.071 | 1.76E-01 | 0.091 | 6.75E-02 | 0.096 | 6.51E-02 | 0.072 | 1.48E-01 | 0.081 | 1.20E-01 | 0.114 | 2.17E-02 | 0.124 | 1.71E-02 | 0.057 | 2.53E-01 | 0.083 | 1.13E-01 | 0.037 | 4.57E-01 | 0.049 | 3.50E-01 | ||
| CD11b(ITGAM) | –0.058 | 2.46E-01 | 0.007 | 8.93E-01 | –0.164 | 8.87E-04 | –0.088 | 9.04E-02 | 0.073 | 1.39E-01 | 0.149 | 4.16E-03 | 0.395 | 1.16E-16 | 0.324 | 1.86E-10 | 0.476 | 1.83E-24 | 0.327 | 1.31E-10 | 0.491 | 0.00E+00 | 0.339 | 2.36E-11 | 0.618 | 0.00E+00 | 0.464 | 4.76E-21 | |||
| CCR7 | –0.184 | 1.93E-04 | –0.146 | 4.87E-03 | 0.246 | 4.70E-07 | 0.266 | 2.13E-07 | –0.17 | 5.69E-04 | –0.166 | 1.39E-03 | 0.005 | 9.19E-01 | –0.046 | 3.80E-01 | 0.035 | 4.78E-01 | –0.035 | 5.07E-01 | 0.125 | 1.15E-02 | 0.031 | 5.56E-01 | 0.167 | 6.98E-04 | 0.104 | 4.61E-02 | |||
| Natural killer cell | KIR2DL1 | –0.072 | 1.48E-01 | –0.055 | 2.96E-01 | –0.108 | 2.95E-02 | –0.055 | 2.92E-01 | 0.068 | 1.70E-01 | 0.077 | 1.39E-01 | 0.147 | 3.00E-03 | 0.063 | 2.26E-01 | 0.171 | 5.36E-04 | 0.042 | 4.21E-01 | 0.153 | 1.97E-03 | 0.033 | 5.30E-01 | 0.249 | 3.40E-07 | 0.108 | 3.80E-02 | ||
| KIR2DL3 | –0.049 | 3.23E-01 | 0.001 | 9.87E-01 | –0.183 | 1.99E-04 | –0.124 | 1.73E-02 | 0.112 | 2.37E-02 | 0.137 | 8.37E-03 | 0.273 | 2.15E-08 | 0.189 | 2.71E-04 | 0.198 | 5.84E-05 | 0.047 | 3.65E-01 | 0.217 | 9.55E-06 | 0.078 | 1.33E-01 | 0.338 | 2.44E-12 | 0.174 | 7.82E-04 | |||
| KIR2DL4 | 0.038 | 4.44E-01 | 0.1 | 5.46E-02 | –0.223 | 5.67E-06 | –0.169 | 1.13E-03 | 0.24 | 9.64E-07 | 0.295 | 7.91E-09 | 0.194 | 7.68E-05 | 0.122 | 1.97E-02 | 0.225 | 4.26E-06 | 0.094 | 7.19E-02 | 0.171 | 5.35E-04 | 0.033 | 5.29E-01 | 0.234 | 1.81E-06 | 0.064 | 2.19E-01 | |||
| KIR3DL1 | –0.045 | 3.60E-01 | –0.01 | 8.52E-01 | –0.11 | 2.63E-02 | –0.051 | 3.29E-01 | 0.043 | 3.84E-01 | 0.035 | 5.05E-01 | 0.229 | 3.05E-06 | 0.173 | 8.84E-04 | 0.154 | 1.78E-03 | 0.044 | 4.02E-01 | 0.21 | 1.98E-05 | 0.124 | 1.74E-02 | 0.29 | 2.42E-09 | 0.191 | 2.26E-04 | |||
| KIR3DL2 | –0.046 | 3.57E-01 | –0.009 | 8.66E-01 | –0.125 | 1.15E-02 | –0.068 | 1.92E-01 | 0.104 | 3.51E-02 | 0.129 | 1.31E-02 | 0.143 | 3.80E-03 | 0.061 | 2.46E-01 | 0.165 | 8.23E-04 | 0.028 | 5.97E-01 | 0.177 | 3.25E-04 | 0.046 | 3.79E-01 | 0.263 | 6.87E-08 | 0.11 | 3.42E-02 | |||
| KIR3DL3 | 0.002 | 9.69E-01 | 0.012 | 8.21E-01 | –0.117 | 1.80E-02 | –0.094 | 7.16E-02 | 0.121 | 1.44E-02 | 0.12 | 2.10E-02 | 0.027 | 5.87E-01 | –0.01 | 8.44E-01 | 0.044 | 3.76E-01 | –0.01 | 8.54E-01 | 0.031 | 5.26E-01 | –0.021 | 6.94E-01 | 0.035 | 4.85E-01 | –0.038 | 4.70E-01 | |||
| KIR2DS4 | –0.065 | 1.93E-01 | –0.029 | 5.77E-01 | –0.161 | 1.12E-03 | –0.109 | 3.71E-02 | 0.13 | 8.62E-03 | 0.137 | 8.29E-03 | 0.176 | 3.68E-04 | 0.094 | 7.09E-02 | 0.126 | 1.08E-02 | –0.004 | 9.39E-01 | 0.15 | 2.44E-03 | 0.032 | 5.44E-01 | 0.217 | 9.83E-06 | 0.068 | 1.94E-01 | |||
| Dendritic cell | HLA-DPB1 | –0.081 | 1.01E-01 | –0.015 | 7.70E-01 | –0.246 | 4.62E-07 | –0.197 | 1.38E-04 | –0.013 | 7.93E-01 | 0.036 | 4.95E-01 | 0.306 | 2.91E-10 | 0.21 | 4.81E-05 | 0.374 | 5.13E-15 | 0.177 | 6.69E-04 | 0.46 | 0.00E+00 | 0.281 | 4.27E-08 | 0.556 | 0.00E+00 | 0.371 | 1.80E-13 | ||
| HLA-DQB1 | –0.011 | 8.27E-01 | 0.079 | 1.29E-01 | –0.222 | 6.15E-06 | –0.173 | 8.41E-04 | 0.015 | 7.69E-01 | 0.063 | 2.30E-01 | 0.288 | 2.98E-09 | 0.2 | 1.13E-04 | 0.33 | 7.54E-12 | 0.154 | 3.07E-03 | 0.395 | 1.14E-16 | 0.231 | 7.51E-06 | 0.46 | 8.45E-23 | 0.253 | 8.98E-07 | |||
| HLA-DRA | 0.02 | 6.93E-01 | 0.111 | 3.33E-02 | –0.252 | 2.51E-07 | –0.197 | 1.42E-04 | 0.062 | 2.11E-01 | 0.117 | 2.50E-02 | 0.299 | 6.93E-10 | 0.207 | 6.31E-05 | 0.351 | 3.06E-13 | 0.168 | 1.22E-03 | 0.438 | 0.00E+00 | 0.272 | 1.13E-07 | 0.513 | 0.00E+00 | 0.324 | 2.01E-10 | |||
| HLA-DPA1 | 0.007 | 8.95E-01 | 0.09 | 8.44E-02 | –0.251 | 2.79E-07 | –0.2 | 1.12E-04 | 0.045 | 3.67E-01 | 0.101 | 5.34E-02 | 0.315 | 7.56E-11 | 0.231 | 7.93E-06 | 0.374 | 5.33E-15 | 0.199 | 1.17E-04 | 0.456 | 2.24E-22 | 0.298 | 5.53E-09 | 0.539 | 3.74E-32 | 0.365 | 5.11E-13 | |||
| BDCA-1(CD1C) | 0.099 | 4.53E-02 | 0.151 | 3.75E-03 | –0.229 | 2.86E-06 | –0.189 | 2.67E-04 | –0.13 | 8.62E-03 | –0.114 | 2.91E-02 | 0.092 | 6.20E-02 | 0.016 | 7.59E-01 | 0.341 | 1.45E-12 | 0.213 | 3.87E-05 | 0.361 | 5.60E-14 | 0.232 | 6.93E-06 | 0.386 | 6.58E-16 | 0.255 | 7.28E-07 | |||
| BDCA-4(NRP1) | 0.172 | 4.78E-04 | 0.216 | 2.82E-05 | –0.225 | 4.40E-06 | –0.182 | 4.59E-04 | 0.294 | 1.76E-09 | 0.357 | 1.62E-12 | 0.397 | 8.04E-17 | 0.334 | 4.91E-11 | 0.608 | 1.22E-42 | 0.533 | 1.92E-28 | 0.569 | 0.00E+00 | 0.532 | 3.08E-28 | 0.661 | 0.00E+00 | 0.592 | 3.21E-36 | |||
| CD11c(ITGAX) | –0.082 | 9.93E-02 | –0.009 | 8.64E-01 | –0.18 | 2.51E-04 | –0.107 | 3.93E-02 | 0.1 | 4.34E-02 | 0.205 | 7.26E-05 | 0.392 | 1.79E-16 | 0.329 | 9.40E-11 | 0.52 | 1.38E-29 | 0.365 | 4.61E-13 | 0.484 | 0.00E+00 | 0.309 | 1.40E-09 | 0.594 | 0.00E+00 | 0.405 | 6.05E-16 | |||
| Th1 | T-bet(TBX21) | –0.035 | 4.77E-01 | 0.027 | 5.99E-01 | –0.187 | 1.49E-04 | –0.127 | 1.50E-02 | 0.091 | 6.71E-02 | 0.143 | 6.01E-03 | 0.297 | 9.41E-10 | 0.191 | 2.36E-04 | 0.342 | 1.19E-12 | 0.154 | 3.00E-03 | 0.347 | 5.35E-13 | 0.161 | 1.98E-03 | 0.477 | 1.47E-24 | 0.273 | 1.05E-07 | ||
| STAT4 | 0.072 | 1.46E-01 | 0.171 | 1.02E-03 | –0.264 | 6.07E-08 | –0.229 | 9.20E-06 | 0.085 | 8.62E-02 | 0.161 | 2.00E-03 | 0.303 | 4.03E-10 | 0.215 | 3.12E-05 | 0.434 | 3.93E-20 | 0.268 | 1.87E-07 | 0.426 | 1.90E-19 | 0.266 | 2.12E-07 | 0.44 | 1.00E-20 | 0.226 | 1.17E-05 | |||
| STAT1 | 0.273 | 2.39E-08 | 0.362 | 7.20E-13 | –0.192 | 9.51E-05 | –0.129 | 1.32E-02 | 0.348 | 6.59E-18 | 0.406 | 4.70E-16 | 0.294 | 1.36E-09 | 0.214 | 3.52E-05 | 0.292 | 1.86E-09 | 0.151 | 3.60E-03 | 0.294 | 1.65E-09 | 0.159 | 2.20E-03 | 0.302 | 5.56E-10 | 0.13 | 1.25E-02 | |||
| IFNG | –0.047 | 3.39E-01 | 0.01 | 8.53E-01 | –0.124 | 1.19E-02 | –0.068 | 1.91E-01 | 0.197 | 6.25E-05 | 0.235 | 5.35E-06 | 0.229 | 3.08E-06 | 0.147 | 4.78E-03 | 0.197 | 6.30E-05 | 0.053 | 3.13E-01 | 0.166 | 7.43E-04 | 0.012 | 8.20E-01 | 0.246 | 4.65E-07 | 0.054 | 3.04E-01 | |||
| TNF | 0.062 | 2.13E-01 | 0.126 | 1.57E-02 | –0.065 | 1.91E-01 | –0.032 | 5.42E-01 | 0.153 | 1.99E-03 | 0.18 | 5.19E-04 | 0.33 | 8.27E-12 | 0.255 | 7.07E-07 | 0.225 | 4.34E-06 | 0.112 | 3.16E-02 | 0.227 | 3.75E-06 | 0.115 | 2.77E-02 | 0.286 | 3.87E-09 | 0.144 | 5.57E-03 | |||
| Th2 | GATA3 | 0.001 | 9.92E-01 | –0.03 | 5.61E-04 | 0.38 | 1.86E-15 | 0.332 | 6.10E-11 | –0.223 | 5.95E-06 | –0.264 | 2.84E-07 | –0.199 | 4.97E-05 | –0.138 | 8.17E-03 | –0.384 | 9.17E-16 | –0.287 | 2.16E-08 | –0.192 | 9.57E-05 | –0.062 | 2.37E-01 | –0.307 | 2.81E-10 | –0.187 | 3.12E-04 | ||
| STAT6 | 0.319 | 5.76E-11 | 0.292 | 1.11E-08 | 0.016 | 7.50E-01 | 0 | 9.95E-01 | –0.048 | 3.32E-01 | –0.086 | 9.80E-02 | –0.033 | 5.06E-01 | –0.005 | 9.19E-01 | –0.092 | 6.45E-02 | –0.039 | 4.61E-01 | –0.05 | 3.17E-01 | 0.034 | 5.13E-01 | –0.118 | 1.74E-02 | –0.05 | 3.35E-01 | |||
| STAT5A | –0.038 | 4.47E-01 | –0.017 | 7.45E-01 | –0.132 | 7.39E-03 | –0.084 | 1.08E-01 | –0.035 | 4.69E-01 | –0.007 | 8.89E-01 | 0.293 | 1.59E-09 | 0.235 | 4.98E-06 | 0.242 | 7.72E-07 | 0.112 | 3.17E-02 | 0.319 | 5.20E-11 | 0.182 | 4.57E-04 | 0.387 | 2.05E-16 | 0.268 | 1.76E-07 | |||
| IL13 | 0 | 9.93E-01 | 0.038 | 4.70E-01 | –0.117 | 1.85E-02 | –0.099 | 5.88E-02 | –0.067 | 1.74E-01 | –0.059 | 2.62E-01 | 0.137 | 5.43E-03 | 0.08 | 1.26E-01 | 0.235 | 1.54E-06 | 0.116 | 2.66E-02 | 0.221 | 6.44E-06 | 0.112 | 3.24E-02 | 0.31 | 1.56E-10 | 0.199 | 1.21E-04 | |||
| Tfh | BCL6 | 0.274 | 1.99E-08 | 0.258 | 5.39E-07 | –0.002 | 9.66E-01 | 0.004 | 9.40E-01 | –0.051 | 3.04E-01 | –0.074 | 1.58E-01 | –0.106 | 3.23E-02 | –0.085 | 1.03E-01 | –0.019 | 6.98E-01 | –0.002 | 9.63E-01 | –0.036 | 4.71E-01 | 0 | 9.99E-01 | –0.088 | 7.62E-02 | –0.051 | 3.28E-01 | ||
| IL21 | –0.045 | 3.70E-01 | –0.005 | 9.25E-01 | –0.061 | 2.22E-01 | –0.022 | 6.67E-01 | 0.138 | 5.37E-03 | 0.166 | 1.39E-03 | 0.185 | 1.72E-04 | 0.147 | 4.79E-03 | 0.148 | 2.78E-03 | 0.089 | 8.67E-02 | 0.126 | 1.06E-02 | 0.049 | 3.46E-01 | 0.275 | 1.71E-08 | 0.22 | 2.07E-05 | |||
| Th17 | IL17A | 0.064 | 2.01E-01 | 0.078 | 1.37E-01 | 0.007 | 8.90E-01 | 0.001 | 9.91E-01 | –0.038 | 4.48E-01 | –0.032 | 5.40E-01 | –0.099 | 4.67E-02 | –0.138 | 8.21E-03 | –0.095 | 5.49E-02 | –0.129 | 1.31E-02 | –0.058 | 2.45E-01 | –0.089 | 8.67E-02 | –0.041 | 4.07E-01 | –0.089 | 8.66E-02 | ||
| STAT3 | 0.457 | 0.00E+00 | 0.511 | 7.46E-26 | –0.224 | 4.73E-06 | –0.172 | 9.05E-04 | 0.311 | 1.67E-10 | 0.334 | 5.21E-11 | 0.366 | 2.35E-14 | 0.308 | 1.66E-09 | 0.392 | 2.06E-16 | 0.289 | 1.61E-08 | 0.375 | 5.17E-15 | 0.29 | 1.38E-08 | 0.32 | 4.42E-11 | 0.204 | 8.13E-05 | |||
| Treg | FOXP3 | 0.124 | 1.21E-02 | 0.238 | 3.86E-06 | –0.191 | 1.04E-04 | –0.141 | 6.79E-03 | 0.159 | 1.33E-03 | 0.238 | 3.82E-06 | 0.339 | 2.10E-12 | 0.262 | 3.37E-07 | 0.433 | 4.16E-20 | 0.31 | 1.16E-09 | 0.458 | 0.00E+00 | 0.335 | 4.48E-11 | 0.543 | 0.00E+00 | 0.398 | 2.19E-15 | ||
| CCR8 | 0.222 | 5.75E-06 | 0.346 | 8.30E-12 | –0.079 | 1.10E-01 | –0.015 | 7.77E-01 | 0.218 | 9.15E-06 | 0.295 | 8.10E-09 | 0.3 | 6.04E-10 | 0.216 | 2.87E-05 | 0.414 | 2.64E-18 | 0.298 | 5.21E-09 | 0.498 | 5.81E-27 | 0.402 | 9.73E-16 | 0.539 | 4.57E-32 | 0.412 | 1.63E-16 | |||
| STAT5B | 0.43 | 0.00E+00 | 0.42 | 3.42E-17 | –0.076 | 1.24E-01 | –0.069 | 1.84E-01 | 0.224 | 5.44E-06 | 0.236 | 4.91E-06 | 0.291 | 1.98E-09 | 0.307 | 1.88E-09 | 0.325 | 1.64E-11 | 0.346 | 9.25E-12 | 0.322 | 3.42E-11 | 0.341 | 1.70E-11 | 0.334 | 5.39E-12 | 0.38 | 4.60E-14 | |||
| TGFB1 | 0.082 | 9.76E-02 | 0.092 | 7.67E-02 | –0.195 | 7.10E-05 | –0.165 | 1.52E-03 | 0.034 | 4.98E-01 | 0.063 | 2.30E-01 | 0.197 | 6.26E-05 | 0.14 | 7.23E-03 | 0.286 | 4.08E-09 | 0.199 | 1.22E-04 | 0.298 | 1.02E-09 | 0.211 | 4.45E-05 | 0.217 | 1.07E-05 | 0.106 | 4.29E-02 | |||
| T cell exhaustion | PD-1(PDCD1) | –0.06 | 2.30E-01 | 0.012 | 8.16E-01 | –0.162 | 1.04E-03 | –0.099 | 5.90E-02 | 0.072 | 1.46E-01 | 0.128 | 1.41E-02 | 0.295 | 1.21E-09 | 0.198 | 1.28E-04 | 0.321 | 3.02E-11 | 0.137 | 8.28E-03 | 0.363 | 3.65E-14 | 0.183 | 4.13E-04 | 0.469 | 1.09E-23 | 0.26 | 4.28E-07 | ||
| CTLA4 | –0.033 | 5.03E-01 | 0.061 | 2.42E-01 | –0.151 | 2.17E-03 | –0.086 | 9.86E-02 | 0.087 | 8.09E-02 | 0.148 | 4.41E-03 | 0.276 | 1.48E-08 | 0.176 | 6.93E-04 | 0.339 | 2.10E-12 | 0.165 | 1.54E-03 | 0.367 | 1.72E-14 | 0.188 | 2.83E-04 | 0.436 | 2.39E-20 | 0.222 | 1.73E-05 | |||
| TIM3(HAVCR2) | –0.041 | 4.09E-01 | 0.044 | 3.97E-01 | –0.243 | 6.76E-07 | –0.186 | 3.37E-04 | 0.132 | 7.83E-03 | 0.235 | 5.38E-06 | 0.35 | 3.57E-13 | 0.262 | 3.26E-07 | 0.474 | 2.93E-24 | 0.305 | 2.28E-09 | 0.478 | 0.00E+00 | 0.308 | 1.50E-09 | 0.59 | 0.00E+00 | 0.41 | 2.53E-16 | |||
| GZMB | –0.091 | 6.56E-02 | –0.019 | 7.22E-01 | –0.154 | 1.85E-03 | –0.075 | 1.51E-01 | 0.103 | 3.75E-02 | 0.17 | 1.09E-03 | 0.254 | 1.96E-07 | 0.152 | 3.48E-03 | 0.302 | 5.07E-10 | 0.096 | 6.58E-02 | 0.304 | 3.36E-10 | 0.105 | 4.47E-02 | 0.37 | 1.02E-14 | 0.124 | 1.70E-02 | |||
| LAG3 | –0.038 | 4.48E-01 | 0.036 | 4.90E-01 | –0.207 | 2.42E-05 | –0.151 | 3.64E-03 | 0.192 | 1.02E-04 | 0.27 | 1.49E-07 | 0.309 | 1.87E-10 | 0.217 | 2.65E-05 | 0.333 | 5.32E-12 | 0.166 | 1.38E-03 | 0.297 | 1.15E-09 | 0.113 | 2.96E-02 | 0.394 | 0.00E+00 | 0.184 | 4.02E-04 | |||