Table 4.

DCE and DWI metrics from whole tumor, tumor without necrosis, and necrosis-only segmentations of necrotic carcinomas

Metric	pCR	Non-pCR	AUC	P-value
DCE (n = 39)	n = 17/39 (44%)	n = 22/39 (56%)
NVDCE (cm3)	5.9 ± 6.8	7.7 ± 10.8	0.59	.37
%NVDCE	14 ± 12	14 ± 10.4	0.50	.99
PE1 TTVDCE	189.2 ± 26	164.37 ± 58	0.51	.97
PE2 TTVDCE	102 ± 12	183.77 ± 51	0.52	.83
PE1 TVDCE	213.17 ± 30.42	184.8 ± 56	0.51	.97
PE2 TVDCE	220.7 ± 14.8	202.6 ± 57	0.53	.77
PE1 NVDCE	58.37 ± 45	64.45 ± 95	0.52	.81
PE2 NVDCE	106.37 ± 67	133.35 ± 97	0.55	.62
DWI (n = 22)	n = 8/22 (36%)	n = 14/22 (64%)
ADC TTVDWI (10−3 mm2/s)	1.26 ± 0.36	1.20 ± 0.22	0.53	.83
ADC TVDWI (10−3 mm2/s)	1.08 ± 0.23	1.13 ± 0.26	0.51	.97
ADC NVDWI (10−3 mm2/s)	1 ± 0.5	1.7 ± 0.3	0.53	.87

Data are mean ± standard deviation unless otherwise indicated

ADC apparent diffusion coefficient, AUC area under the receiver operating characteristics curve, DCE dynamic contrast-enhanced, DWI diffusion-weighted imaging, pCR pathological complete response, NV volume of necrosis, %NV percent of necrosis, PE1 percent enhancement at early phase, PE2 percent enhancement at delayed phase, TTV total tumor volume including necrosis, TV tumor volume excluding necrosis