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. 2021 Jul 2;12:695957. doi: 10.3389/fphar.2021.695957

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Copyright © 2021 Liu, Wu, Lin, Xie, Liu, Huang, Zeng, Yang, Wang, Dong, Deng, Yang, Wu, Jiang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic represent IL-17 family subgroup and their corresponding receptors from IL-17 receptor family. IL-17A, IL-17A/F and IL-17F share the IL-17RA/RC heterodimeric receptor. The intracellular domains of all IL-17R encode conserved SEFIR domains which interact with a corresponding SEFIR motif on the adaptor Act1, then they combine with TRAF6 to activate the pathway of NF-κB and MAPK. However, TRAF3 could inhibit SEFIR- Act1- TRAF6 pathway by competitive binding the IL-17RA directly. Only IL-17RA own the CBAD and TILL, which can promote the target gene expressions via C/EBP β pathway.