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IL-17A promotes neutrophils infiltration and lung destruction by increasing p53 and PAI-1. Both p53 and PAI-1 can induce the apoptosis of alveolar epithelial cells, while PAI-1 inhibits the neutrophil apoptosis and fibrinolysis in lung tissue. Besides, IL-17A induces the expression of IL-8, G-CSF and CXCL2, which recruits neutrophils producing neutrophil elastase and myeloperoxidase, giving rise to the destruction of alveolar wall and emphysema.
