FIGURE 4.

IL-17A induces gene expression by activating IKK-α. Schematic show the pathway of inflammation-associated gene expression directly regulated by activated IKK-α through direct translocation into nucleus after receiving the stimulation of increased IL-17A. After phosphorylation and acetylation of H3, the target genes’ chromatin will be recombined and bind to NF-κB to promote TSLP expression. Then TSLP will combine with its receptor on immature dendritic cells and T helper cells to promote the differentiation and immune response of Th2 in COPD lung tissue.