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. 2021 Jul 2;12:695957. doi: 10.3389/fphar.2021.695957

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Copyright © 2021 Liu, Wu, Lin, Xie, Liu, Huang, Zeng, Yang, Wang, Dong, Deng, Yang, Wu, Jiang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BYF alleviates COPD symptoms by promoting the expression of pro-inflammatory factors and suppressing the production of anti-inflammatory cytokines. BYF induces T naïve cells towards Tregs, producing IL-10, by up-regulating the FOXP3 expression via STAT5 pathway, while it inhibits the differentiation of Th17 cells, producing IL-17A, by down-regulating the RORγt gene via STAT3 pathway. Meanwhile, BYF also decrease the levels of pro-inflammatory cytokines such as IL-1β, IL-6 and TNF-α, which could alleviate the inflammation development of COPD.