. 2021 Mar 10;7(4):1131–1143. doi: 10.1002/vms3.469

TABLE 4.

Evaluation of patient characteristics, environmental factors and fCalR in healthy dogs (n = 142)

Variable	Fecal calprotectin/S100A12 ratio (fCalR)
Variable	n	Fecal concentration, median [range]	P (univariate analysis)	P (multi‐variate analysis)
Age
≤1 year	13	33 [3–3,164]	0.6283 (χ ² = 1.739, df = 3)	ns
1–3 years	55	73 [0–2,503]
4–7 years	41	97 [1–1,091]
≥7 years	2	84 [2–1,785]
Sex
Male	60	76 [2–1,205]	0.8704 (Z = −0.163)	ns
Female	82	82 [0–3,164]	0.8704 (Z = −0.163)	ns
Reproductive status
Intact	35	52 [0–3,164]	0.0635 (Z = −1.856)	0.1496 (F _{(1, 83)} = 2.116)
Neutered/spayed	102	97 [1–2,503]	0.0635 (Z = −1.856)	0.1496 (F _{(1, 83)} = 2.116)
Males: reproductive status
Intact	15	94 [6–1,205]	0.2766 (Z = 1.088)	—
Neutered	44	76 [2–1,046]	0.2766 (Z = 1.088)	—
Females: reproductive status
Intact	58	17 [0–3,164]	0.0012 (Z = −3.233)	—
Spayed	20	113 [1–2,503]	0.0012 (Z = −3.233)	—
Body condition (based on BCS)
Underconditioned ^a	1	11	0.4023 (χ ² = 1.821, df = 2)	ns
Ideal body condition ^b	96	92 [2–3,164]
Overconditioned ^c	25	71 [1–2,503]
Breed size
Small breed ^d	27	36 [0–910]	0.0462 (χ ² = 6.150, df = 2)	0.6800 (F _{2, 108)} = 0.387)
Medium‐size breed ^e	36	120 [5–3,164]
Large breed ^f	78	75 [2–1,785]
Breed
Pure‐bred dogs	98	74 [0–3,164]	0.1178 (Z = 1.564)	0.1409 (F _{(1, 107)} = 2.200)
Mixed‐breed dogs	44	130 [3–2,503]	0.1178 (Z = 1.564)	0.1409 (F _{(1, 107)} = 2.200)
Diet
Premium diet	84	92 [0–3,164]	0.9650 (Z = −0.044)	ns
Supermarket diet	46	74 [2–2,503]	0.9650 (Z = −0.044)	ns
Primary environment
Indoor	110	91 [2–2,503]	0.7425 (χ ² = 0.595, df = 2)	ns
Indoor + outdoor access	11	73 [1–3,164]
Outdoor	4	106 [66–645]
Travel history
Yes	23	67 [2–3,164]	0.6355 (Z = −0.474)	ns
No	84	103 [2–2,503]	0.6355 (Z = −0.474)	ns
Current vaccination
Yes ^g	92	92 [1–3,164]	0.2873 (Z = −1.084)	ns
No ^h	22	72 [2–770]	0.2873 (Z = −1.084)	ns
Yes + CPV2 included	55	91 [1–3,164]	0.9352 (Z = −0.081)	ns
Yes + CPV2 not included	21	80 [2–1,430]	0.9352 (Z = −0.081)	ns
Recent vaccination
Yes ⁱ	16	45 [1–1,430]	0.2135 (Z = −1.244)	0.5320 (F _{(1, 107)} = 0.393)
No ^j	98	89 [2–3,164]	0.2135 (Z = −1.244)	0.5320 (F _{(1, 107)} = 0.393)
Yes + CPV2 included	11	28 [1–219]	0.1611 (Z = 1.401)	—
Yes + CPV2 not included	3	626 [15–1,430]	0.1611 (Z = 1.401)	—
Recent endoparasite treatment Recent endoparasite treatment
Yes ^k	49	73 [1–1,785]	0.9327 (Z = −0.085)	ns
No ^l	36	69 [2–3,164]

BCS, body condition score; CPV2, canine parvovirus type‐2. P‐values in bold font indicate a significant effect (p < .05).

^{^a}

Body condition score (BCS): <2.5 of 5.

^{^b}

BCS = 2.5 or 3.

^{^c}

BCS: >3 of 5.

^{^d}

Average adult body weight: <10 kg.

^{^e}

Average adult body weight: 10–25 kg.

^{^f}

Average adult body weight: >25 kg.

^{^g}

Within 12 months of fecal sample collection.

^{^h}

Last vaccination > 12 months ago.

^ⁱ

Within 4 weeks of fecal sample collection.

^{^j}

Last vaccination > 4 weeks ago.

^{^k}

Last endoparasite treatment within 3 months of fecal sample collection.

^{^l}

Last endoparasite treatment > 3 months ago.