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. 2021 Jul 7;12:645563. doi: 10.3389/fendo.2021.645563

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Copyright © 2021 Smits and Van Raalte

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Course of nausea with semaglutide. GLP-1RA, including semaglutide, cause nausea in about one third of treated patients, which is both dose- and time-dependent. In panel (A), a direct comparison between subcutaneous and oral semaglutide is shown, as well as different doses of oral semaglutide, for the first occurrence of nausea. In panel (B), the course of the occurrence of nausea is shown for subcutaneous semaglutide. Data for panel (A) are derived from the phase-2 trial (38), for panel (B) data are shown from (26). GLP-1RA, glucagon-like peptide-1 receptor agonist.