Figure 2 .

Effect of data selection on network topology: seen here are the networks of the protein insulin with different criteria for selection of its interactions, built using the STRING [96] database. While one can chose interactions with lower confidence to allow scope for exploration of possible links, it leads to a denser structure. As more stringent criteria is applied, while the quality of interactions is higher, possibilities of discovering potentially novel interactions decreases. The effect on topology is prominent, and would directly affect analysis and prediction based on these different networks.