Fig 2. Venn diagram of up- and down-regulated genes that were differentially expressed by pre- and postexposure samples in male and female rhesus macaques.

An overlapping number of genes being similarly up- and down-regulated in both sexes are presented by the numbers in the overlapping circles. The number of genes differentially expressed in males or females only is shown outside the overlapping circle. Numbers in parenthesis represent the total number of differentially expressed genes in males and females. Based on the fold-change, the p-value and the preference to genes differentially expressed in both sexes, 37 candidate genes were selected and put forward in phase II for validation purposes.