Table 1:
Broad germline sequencing studies of pediatric cancer with >100 patients
| Study | Hematologic | Central nervous system | Solid tumor (non-CNS) | Percent reported with germline P/LP variants in high/moderate penetrance cancer predisposition genes |
|---|---|---|---|---|
| Michigan – Mody et al. JAMA 2015 | 30 | 8 | 64 | 10% |
| St. Jude – Zhang et al. NEJM 2015 | 588 | 245 | 287 | 8% |
| Baylor – Parsons et al. JAMA Oncology 2016 | 56 | 94 | 10% | |
| Columbia – Oberg et al. Genomic Medicine 2016 | 36 | 16 | 49 | 10% |
| Australia – Wong et al. 2020 | 43 | 92 | 112 | 11% |
| MSKCC – present study | 139 | 612 | 13% |