Figure 2.

Platelets are activated in mice following hypoxia exposure. A: platelets from mice exposed to hypoxia have similar levels of P-selectin expression at baseline (unstimulated), ns, not significant; n = 12–13 rats (sex not recorded). B: platelets from mice exposed to hypoxia for both 1 day and 3 days have increased expression of P-selectin after thrombin stimulation compared with controls, *P < 0.05 by one-way ANOVA, n = 10–14 rats (sex not recorded). C: increased platelet-monocyte aggregates following exposure to hypoxia, *P < 0.0001 by t test, n = number of rats; NMX: n = 7 male 5 female; HPX: n = 2 male 3 female. D: plasma CXCL4 levels from mice following hypoxia are increased compared with controls, *P < 0.05 by t test; NMX: n = 5 male 4 female; 3D HPX: n = 6 male 2 female. HPX, hypoxia; NMX, normoxia.