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. 2020 Dec 2;320(3):L413–L421. doi: 10.1152/ajplung.00519.2020

Figure 3.

Figure 3.

Platelet depletion prevents inflammation in mice exposed to hypoxia. A: antibody-mediated platelet depletion results in profound thrombocytopenia that persists throughout the study period, *P < 0.001, n = number of rats, NMX: n = 5 male; HPX, n = 10 male, 2 female. Platelet depletion prevents hypoxia-induced increase in plasma CXCL4 *P < 0.05, NMX vs. 3D HPX, **P < 0.005 (B). 3D HPX + platelet depletion vs. NMX and 3D HPX by one-way ANOVA; NMX: n = 5 male, 4 female; 3D HPX: n = 6 male, 2 female; 3D HPX + platelet depletion: n = 5 male, and plasma CCL5, *P < 0.05, 3D HPX + platelet depletion vs. NMX and 3D HPX by one-way ANOVA; NMX: n = 4 male; 3D HPX: n = 6 male; 3D HPX + platelet depletion: n = 7 male (C). Platelet depletion attenuates hypoxia-associated increase in Plasma CSF-2, *P < 0.005, NMX vs. 3D HPX and **P < 0.05, 3D HPX vs. 3D HPX + platelet depletion by one-way ANOVA, NMX: n = 5 M, 3 D HPX: n = 5 M, 3 D HPX + platelet depletion: n = 7 M (D). Platelet depletion prevents hypoxia-induced expansion of lung interstitial macrophages, *P < 0.001, NMX vs. 3D HPX and **P < 0.05 3D HPX vs. 3D HPX + platelet depletion by one-way ANOVA; NMX: n = 6 male; HPX: n = 6 male, 3D HPX + platelet depletion: n = 7 male (E). HPX, hypoxia; NMX, normoxia.