Figure 2.

Recently investigated long noncoding RNAs (lncRNAs) regulate processes critical to T cell function such as survival, proliferation, and lineage-specific gene expression. The lncRNAs act through distinct mechanisms at different levels within known signaling pathways, demonstrating their dynamic and versatile nature. Although many lncRNAs are known to act in a competitive or synergistic manner within a single system, further studies are required to understand the relationship between the lncRNAs shown in this schematic, as the summarized data were collected in different models under different conditions. ARIEL, ARID5B-inducing enhancer-associated long noncoding RNA; PI3K, phosphatidylinositol 3-kinase; Th1, T helper 1; Th2, T helper 2; Th17, T helper 17.