Table 1.
List of the lncRNAs covered in this review and a brief description of their function
| lncRNA | Cell Type | Role | Ref. Nos. |
|---|---|---|---|
| ARIEL | CD4+ T cells | Positive regulator of TAL1 and MYC | 16, 26 |
| GATA3-AS1 | CD4+ Th2 | Positive regulator of GATA3 | 44 |
| HEAL | CD4+ T cells | Positive regulator of HIV replication | 25 |
| IFNG-AS1 | CD4+ Th1, CD8+ T effector | Positive regulator IFNγ production | 15, 47–49 |
| LINC01882 | CD4+ T cells | Negative regulator of KLF12 and the MAPK pathway | 10 |
| linc-MAF-4 | CD4+ T cells | Negative regulator of MAF | 17 |
| lnc-EGFR | CD4+ T cells | Positive regulator of FOXP3 | 13 |
| lnc-ITSN1-2 | CD4+ Th17 | Positive regulator of IL-23R | 50 |
| lnc-TIM3 | CD8+ T cells | Positive regulator of MDM2 and BCL2 | 12 |
| MALAT1 | CD4+ T cells | Negative regulator of epigenetic silencing at HIV proviral locus | 51 |
| Morrbid | CD8+ T cells | Negative regulator of PI3K-AKT | 14 |
| Morrbid | CD8+ T cells, CD4+ effector memory, CD4+ central memory | Positive regulator of Bcl2l11 | 14 |
| NEAT1 | CD4+ Th1, CD8+ T effector | Negative regulator of IFN-γ production | 9 |
| NEAT1 | CD4+ T cells | Negative regulator of HIV replication | 52 |
| NKILA | CD8+ T cells, CD4+ Th1 | Negative regulator of NF-κB | 11 |
| NRON | CD4+ T cells | Negative regulator of HIV proviral transcription | 53 |
| PVT1 | CD4+ T cells | Positive regulator of MYC | 8 |
| XIST | CD4+ T cells | Negative regulator of X-linked genes involved in cell cycle control | 54 |
| XLOC_000261 | CD4+ Th17 | Negative regulator of RORγt | 55 |
The T cell subset(s) in which each long noncoding RNA (lncRNA) has been reported to carry out the specified regulatory role(s) are shown. Morrbid and NEAT1 have multiple known functions that are listed as separate entries based on the T cell subset(s) studied in each case. Many of the described lncRNAs have additional functions in non-lymphocytic cells, which have not been included in this table. ARIEL, ARID5B-inducing enhancer-associated long noncoding RNA; Th2, T helper 2; Th1, T helper 1; Th17, T helper 17; PI3K, phosphatidylinositol 3-kinase.