Figure 1.

Message RNA abundance of the seven cation-chloride cotransporters in tissues. Representative panels showing the abundance of Na-K-2Cl cotransporter-1 (NKCC1), Na-K-2Cl cotransporter-2 (NKCC2), Na-Cl cotransporter (NCC), and K-Cl cotransporter-1–4 (KCC1-4) in 19 selected tissues. As highlighted by the arrows, NKCC2 and NCC are almost exclusively expressed in kidney, whereas KCC2 expression is abundant in the central nervous system. Values are given as Normalized eXpression (NX). Note that NX values for NKCC2 and NCC in kidney far exceed the scale, which is represented by the broken bars. The NX values are given for these two bars. Data were collected and redrawn from the Human protein atlas (https://www.proteinatlas.org/).