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. 2020 Dec 23;320(3):C324–C340. doi: 10.1152/ajpcell.00566.2020

Figure 5.

Figure 5.

Two classes of diuretics (thiazide and loop) share structure similarities. Hydrochlorothiazide and furosemide have conserved phenol rings with a Cl ion and a sulfonamide group. Furosemide and bumetanide share the sulfamoylbenzoic acid but the Cl ion in furosemide is replaced with a phenoxy group. Conserved groups in structures are highlighted by the gray background.