Table 2.

Thirty-Day All-Cause Mortality for Ondansetron Groups for Specific Subgroups

	Group 0 (n = 9540)	Group 1 (n = 750)	Group 2 (n = 451)	P Value Comparing Groups 0 and 1	P Value Comparing Groups 0 and 2	P Value Comparing Groups 0 and 1/2
Overall, %	17.5	13.5	10.6	.005**	<.001***	<.001***
Non-ICU, %	14.9	10.7	9.7	.006**	.008**	<.001**
ICU, %	26.8	24.7	15.0	.628	.026*	.070
Obesity, %	12.3	13.3	8.6	.863	.524	.232
Ventilation, %	39.4	26.2	20.8	.126	.107	<.001***
Intubation, %	58.8	62.0	52.2	.765	.676	.984
Hypertension, %	18.5	14.9	12.3	.038*	.007**	<.001***
Diabetes, %	18.2	16.7	15.2	.529	.298	.222
Moderate or severe kidney disease, %	24.1	20.4	16.7	.362	.213	.114
COPD/emphysema, %	19.8	18.1	13.3	.588	.128	.161
Cancer history, %	20.3	18.3	13.8	.500	.101	.117
Female, %	10.1	6.7	4.8	.47	.260	.124
African American or Black, %	15.1	10.8	11.4	.103	.296	.041*
Hispanic or Latino, %	15.9	16.9	10.0	.961	.435	.686
Age group 1: ≤49, %	2.4	3.1	1.7	.851	.897	.960
Age group 2: 50–59, %	5.0	5.8	6.4	.874	.777	.544
Age group 3: 60–69, %	12.4	13.2	9.8	.816	.530	.877
Age group 4: ≥70, %	23.6	21.1	20.1	.374	.372	.182

Groups were defined as follows: ICU = patients who were in the ICU at any time during their COVID-19 admission; non-ICU = patients who were never in the ICU during their COVID-19 admission; hypertension = patients with an ICD-10 code of hypertension in the prior 3 years; obesity = patients with either a BMI ≥30 kg/m² in the past year or an ICD-10 code of obesity in the prior 3 years; diabetes = patients with an ICD-10 code of diabetes in the prior 3 years; Hispanic = patients who self-identified in 2019–2020 as Hispanic or Latino; African American = patients who self-identified in 2020 as Black or African American.

Abbreviations: BMI, body mass index; COPD, chronic obstructive pulmonary disease; COVID-19, coronavirus disease 2019; ICD-10, International Classification of Diseases, Tenth Revision; ICU, intensive care unit.

*P < .05; ^**P < .01; ^***P < .001.