TABLE 2.
Univariate Cox analysis of ferroptosis-related genes in TCGA cohort.
| Official symbol | Classification | HR | HR.95L | HR.95H | p-value |
| SLC7A11 | Suppressor, marker | 1.1436 | 1.0264 | 1.2741 | 0.0150 |
| GCLC | Suppressor | 1.1311 | 1.0274 | 1.2453 | 0.0120 |
| SLC3A2 | Suppressor, marker | 1.2903 | 1.0164 | 1.6379 | 0.0363 |
| CISD1 | Suppressor | 1.4746 | 1.0815 | 2.0106 | 0.0141 |
| FANCD2 | Suppressor | 1.4818 | 1.1262 | 1.9496 | 0.0050 |
| HELLS | Suppressor | 1.2736 | 1.0203 | 1.5899 | 0.0326 |
| VDAC2 | Driver, suppressor | 1.5990 | 1.2089 | 2.1150 | 0.0010 |
| CISD2 | Suppressor | 1.4245 | 1.0326 | 1.9651 | 0.0311 |
| ISCU | Suppressor | 0.5316 | 0.3645 | 0.7753 | 0.0010 |
| ACSL3 | Suppressor | 1.4123 | 1.1310 | 1.7635 | 0.0023 |
| ARNTL | Suppressor | 0.6487 | 0.4691 | 0.8971 | 0.0089 |
| ATP5MC3 | Driver, marker | 1.3624 | 1.0458 | 1.7748 | 0.0219 |
| DUOX1 | Driver | 0.8690 | 0.7636 | 0.9891 | 0.0335 |
| PGD | Driver | 1.1832 | 1.0226 | 1.3691 | 0.0238 |
| FLT3 | Driver | 0.4923 | 0.2676 | 0.9058 | 0.0227 |
| NRAS | Driver | 1.3643 | 1.0743 | 1.7327 | 0.0108 |
| KRAS | Driver | 1.3267 | 1.0652 | 1.6524 | 0.0116 |
| GLS2 | Driver | 0.3929 | 0.1930 | 0.8000 | 0.0100 |
| ALOX12B | Driver | 1.5515 | 1.0374 | 2.3206 | 0.0325 |
| ALOX15 | Driver, marker | 0.8494 | 0.7296 | 0.9890 | 0.0355 |
| ALOX15B | Driver | 0.9102 | 0.8330 | 0.9946 | 0.0375 |
| ALOXE3 | Driver | 1.6274 | 1.0031 | 2.6403 | 0.0486 |
| PHKG2 | Driver | 0.7183 | 0.5258 | 0.9814 | 0.0377 |
| DPP4 | Driver | 0.9036 | 0.8279 | 0.9863 | 0.0233 |
| PEBP1 | Driver | 0.6239 | 0.4811 | 0.8091 | 0.0004 |
| CDO1 | Driver | 0.7163 | 0.5199 | 0.9870 | 0.0413 |
| PANX1 | Driver | 1.3978 | 1.0663 | 1.8323 | 0.0153 |
| UBC | Marker | 1.4774 | 1.0163 | 2.1477 | 0.0409 |
| TXNRD1 | Marker | 1.1429 | 1.0354 | 1.2615 | 0.0081 |
| SRXN1 | Marker | 1.1887 | 1.0130 | 1.3949 | 0.0341 |
| GPX2 | Marker | 1.0511 | 1.0004 | 1.1043 | 0.0481 |
| DDIT4 | Marker | 1.2211 | 1.0740 | 1.3883 | 0.0023 |
| TSC22D3 | Marker | 0.8428 | 0.7269 | 0.9771 | 0.0234 |
| SLC7A5 | Marker | 1.1724 | 1.0379 | 1.3244 | 0.0105 |
| HERPUD1 | Marker | 0.6625 | 0.5232 | 0.8389 | 0.0006 |
| GDF15 | Marker | 0.8923 | 0.8103 | 0.9825 | 0.0204 |
| CEBPG | Marker | 1.3520 | 1.0752 | 1.6999 | 0.0099 |
| EIF2S1 | Marker | 1.7254 | 1.2530 | 2.3757 | 0.0008 |
| RELA | Marker | 1.6419 | 1.0522 | 2.5623 | 0.0290 |
| IL33 | Marker | 0.8559 | 0.7507 | 0.9758 | 0.0200 |
| SLC2A1 | Marker | 1.2901 | 1.1569 | 1.4386 | 0.0000 |
| RRM2 | Marker | 1.3596 | 1.1913 | 1.5517 | 0.0000 |
| HNF4A | Marker | 1.2844 | 1.1014 | 1.4978 | 0.0014 |
| YWHAE | Marker | 1.4306 | 1.0352 | 1.9769 | 0.0300 |
| AURKA | Marker | 1.3003 | 1.1259 | 1.5018 | 0.0004 |