Table 6. Prediction performance for 6-month treatment outcomes.

Target	Model	Validation BS	Testing BS
<6.5%	RF	0.2042 (0.0308)	0.1612
	GBT	0.1886 (0.0320)	0.1587
	TPGE	0.1532 (0.0026)	0.1560
<7.0%	RF	0.2842 (0.0869)	0.1896
	GBT	0.1912 (0.0330)	0.1645
	TPGE	0.1526 (0.0023)	0.1617
<7.5%	RF	0.1835 (0.0511)	0.1600
	GBT	0.1841 (0.0518)	0.1387
	TPGE	0.1318 (0.0031)	0.1392
<8.0%	RF	0.1390 (0.0384)	0.1206
	GBT	0.1390 (0.0384)	0.1066
	TPGE	0.1020 (0.0016)	0.1067
<8.5%	RF	0.2244 (0.1525)	0.0897
	GBT	0.1077 (0.0436)	0.0792
	TPGE	0.0763 (0.0015)	0.0777
Average	RF	0.2070 (0.0719)	0.1442
	GBT	0.1621 (0.0398)	0.1295
	TPGE	0.1232 (0.0022)	0.1283

Abbreviations: BS, Brier Score; GBT, Gradient Boosting Tree; RF, Random Forest; TPGE, Treatment Pathway Graph-based Estimation.

Note: Parentheses denote standard deviations in cross validation.