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(A) Estradiol, endogenous ligand; identified bioactive flavonoids present in hops, licorice (mainly Glycyrrhiza inflata (GI)), Epimedium species (e.g., E. sagittatum) sold as horny goat weed, and present in ubiquitous plant sources as indicated. (B) Identified bioactive isoflavonoids present in red clover/soy and lupin bean, as well as DGN, a biotransformed metabolite of GEN.
