Table 2.
Comparison of antioxidant status and glucose concentration in urine among studied groups.
| Variables | T2DM patients not treated with SGLT2i (1), n = 31 | T2DM patients treated with SGLT2i (2), n = 37 | Healthy controls (3), n = 33 | p ANOVA |
|---|---|---|---|---|
| Total SOD [NU/ml] | 25.2 (8.9-35.8; 95% CI: 21.1-26.2)a | 28.5 (16.7-36.0; 95% CI: 26.1-29.4)a,b | 23.2 (9.7-25.1; 95% CI: 20.2-25.2)b | <0.01 |
| MnSOD [NU/ml] | 22.6 (8.6-35.9; 95% CI: 19.1-24.4)c | 27.1 (14.3-35.9; 95% CI: 24.9-28.5)c,d | 21.6 (8.34-35.1; 95% CI: 18.8-23.9)d | <0.001 |
| TAC [mmol/l] | 9.9 (0.0-45.8; 95% CI: 7.9-14.6)e | 7.9 (0.0-29.1; 95% CI: 6.5-11.7)e,f | 9.2 (0.4-51.2; 95% CI: 8.4-15.2)f | <0.05 |
| R-SH [μmol/l] | 1.7 (0.0-51.0; 95% CI: 4.5-16.2)g | 1.9 (0.0-54.7; 95% CI: 3.4-11.8)h | 13.6 (0.0-117.9; 95% CI: 10.8-30.6)g,h | <0.05 |
| CAT [IU/l] | 2.9 (1.0-8.4; 95% CI: 2.5-3.6) | 3.4 (1.3-16.4; 95% CI: 3.2-4.9) | 2.6 (0.6-9.5; 95% CI: 2.3-3.6) | >0.05 |
| Urinary glucose concentration [mg/dl] | 305 (49.0-3346.3; 95% CI: 269.9-897.7)i,j | 2699.3 (85.7-3447.7; 95% CI: 2190.9-2742.0)i,k | 2.8 (0.0-9.4 95% CI: 2.0-3.7) j,k | <0.001 |