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. 2021 Jul 6;59(2):61. doi: 10.3892/ijo.2021.5241

Figure 5.

Figure 5

Effects of the tetrahydrothieno[2,3-c]pyridine 3b and PNA-a221 on the cell cycle and on the proportion of the sub-G1 population. U251 cells were treated with the indicated concentrations of compound 3b and R8-PNA-a221 and the cell cycle distribution was determined. (A) Representative cell cycle analyses. (B) Proportion of U251 cells in the G1, S and G2/M phase of the cell cycle (sub-G1 cells excluded from the calculations). (C) Increase in the sub-G1 cell population following treatment of the U251 cells with compound 3b, PNA-a221 or both 3b and PNA-a221 used in combination. PNA, peptide nucleic acid. *P<0.05, **P<0.01, vs. untreated cells.