. Author manuscript; available in PMC: 2022 May 1.

Published in final edited form as: J Physiol Biochem. 2021 Feb 17;77(2):295–304. doi: 10.1007/s13105-021-00797-x

Table 3.

Association between treatment and change in methylation markers from baseline to week 24.

Model^§	Estimate (95% CI)	P-value
change in SAM from baseline to week 24^*	1.186 (−1.009, 3.381)	0.2892
change in SAH from baseline to week 24^*	0.810 (0.000, 1.621)	0.0501
change in SAM/SAH from baseline to week 24^*	−103.110 (−261.568, 55.348)	0.2021

^§

Box-Cox transformation was applied to models that violated normality assumption.

Placebo and male groups were used as reference groups. Models adjusted for gender, age at baseline, baseline value of specific DNA methylation marker, baseline creatinine and baseline GFR.