. Author manuscript; available in PMC: 2022 May 1.

Published in final edited form as: J Physiol Biochem. 2021 Feb 17;77(2):295–304. doi: 10.1007/s13105-021-00797-x

Table 5.

Associations between changes in SAM/SAH ratio from baseline to week 24 and outcomes

Outcome	Estimate (95% CI)	P-value
Change in left ventricular diastolic volume index from baseline to week 24 (ml/m2)^*	0.000 (−0.015, 0.015)	0.995
Change in left ventricular systolic volume index from baseline to week 24 (ml/m2)^*	0.003 (−0.010, 0.016)	0.639
Log Left ventricular mass index at week 24 (gm/m2)^*	−0.004 (−0.015, 0.006)	0.430
Change in left ventricular ejection fraction from baseline to week 24 (%)^*	−0.001 (−0.003, 0.001)	0.508
KCCQ overall summary score at week 24^**	−0.001 (−0.029, 0.027)	0.928
Change in 6-minute walk distance^*	−0.005 (−0.022, 0.012)	0.574

Model adjusted for baseline value of the parameter, treatment arm, gender, age, baseline creatinine and estimated glomerular filtration rate. Appropriate transformation was used where normality assumption was violated.

^**

Model adjusted for treatment arm, gender, age, baseline creatinine and estimated glomerular filtration rate.

Male group and placebo group were used as reference groups in all models.

KCCG, Kansas City Cardiomyopathy Questionnaire; SAM, S-adenosyl methionine; SAH, S-adenosyl homocysteine