Table 2.
Mouse microbial QTL mapping studies
| Publication | # Strains | Population | Number of Loci | Statistical criteria | Source | Target |
|---|---|---|---|---|---|---|
| (Benson et al. 2010) | 645 animals | G4 AIL (B6J x ICR) | 18 | Significant or suggestive | Fecal pellets | 16S V1‐2 |
| (Hillhouse et al. 2011) | 314 animals | F2 (B6 x AJ) | 10 | Significant | Cecal contents | Helicobacter |
| (McKnite et al. 2012) | 61 animals (30 Strains) | RI (BXD) | 9 | Significant | Fecal pellets | 16S V1‐2 |
| (Leamy et al. 2014) | 472 animals | G10 AIL (B6J x ICR) | 42 | 1 significant post FDR | Fecal pellets | 16S V1‐2 |
| (Org et al. 2015) | 599 (110 Strains) | HDMP | 7 | Significant | Cecal contents | 16S V4 |
| (Wang et al. 2015) | 334 animals | F2( WSB/EiJ x PWH/PhJ) | 20 | Significant | Cecal contents | 16S V1‐2 |
| (Snijders et al. 2016) | 293 animals (30 Strains) | RI (CC) | 169 | − log10(P value) > 6) | Fecal pellets | 16S V4 |
| (Kemis et al. 2019) | 500 animals | Outbred (DO) | 28 | 4 Significant | Fecal pellets | 16S V4 |
| (Perez‐Munoz et al. 2019) | ~ 128 animals (32 Strains) | RI (BXD) | 27 | Significant | Cecal contents | 16S V5‐V6 |
| (Suzuki et al. 2019) | 70 wild animals | Wild Mice | 24 | − log10(p value) > 6) | Cecal contents and fecal pellets | 16S V4 |
| (Bubier et al. 2020) | 201 animals (108 Strains) | RI (pre‐CC) | 18 | Significant post FDR | Cecal contents | 16S V1‐2, V4 |