Table 1.
Distinct features of the wild immune system
| Numbers | Species | Source of animals | Tissues | Major findings | Assays | References |
|---|---|---|---|---|---|---|
| 1 | Peromyscus leucopus, Microtus pinetorum, Perognathus hispidus, Neotoma Jloriakna, Onychomys leucogaster, Mus musculus | Central Oklahoma (USA) | Blood | -Increased primary immunoresponsiveness to SRBC | Splenic plaque-forming cell assay | Lochmiller RL et al. (1991) |
| 2 | Mus musculus | Bristol (UK) | Blood, spleen |
-Enhanced antibody production against keyhole limpet hemocyanin (KLH) immunization -Overall activation status of immune cells (T cells, B cells, DCs, and Macrophage) |
KLH immunization and flow cytometric (FACs) analysis | Abolins SR et al. (2011) |
| 3 | Mus musculus | southeastern Norway | Spleen | -Primed status of NK cells (Increase of CD69, KLRG1, GRAZYME B, IFNγ and NKp46 expression, and CD27+CD11b−population) | FACs analysis | Boysen P et al. (2011) |
| 4 | Mus musculus | Minnesota and Georgia (USA) | Blood, spleen | -Primed status of CD8+ T cells (increase of CD44+CD62L− T cells) | Serological, FACs, and RNAseq analysis | Beura LK et al. (2016) |
| 5 | Mus musculus | Bristol and Stroud (UK) | Blood, spleen |
-Higher level of serum Proteins (IgG, IgE, SAP, Haptoglobin) -Highly primed state of overall immune population (CD44+CD62− T cells, CD27+CD11b− NK cells) |
Serological and FACs analysis | Abolins S et al. (2017) |
| 6 | Mus musculus | Maryland and Columbia (USA) | Blood, spleen, liver, vagina, skin, and gut | -Enrichment of immune responses/activation signature in PBMC | CyTOF and RNAseq analysis | Lavrinienko A et al. (2018) |