Table 2.
Summary and association of baseline demographics and laboratory values with an elevated methotrexate level at 48 h after the first HDMTX dose
| Characteristic | Initial cycle (N = 321) | Odds ratio† (95% CI) | p-value |
|---|---|---|---|
| Age (year), median (IQR) | 64.9 (56.7, 72.2) | 1.02 (1.00, 1.04) | 0.053 |
| Male, no. (%) | 190 (59.2%) | 2.16 (1.25, 3.72) | 0.006 |
| Race, no. (%) | |||
| Caucasian | 293 (91.3%) | 5.11 (1.19, 22.0) | 0.029 |
| Other/unknown | 28 (8.7%) | Reference | |
| Body surface area, median (IQR) | 2.0 (1.8, 2.1) | 1.18 (1.08, 1.30)‡ | <0.001 |
| Lymphoma diagnosis subtype, no. (%) | |||
| Diffuse large B-cell lymphoma (DLBCL) | 132 (41.1%) | Reference | |
| Primary DLBCL of the CNS | 106 (33.0%) | 2.41 (1.31, 4.45) | 0.005 |
| EBV positive DLBCL of elderly | 10 (31.2%) | 1.20 (0.24, 6.06) | 0.82 |
| Other | 73 (22.7%) | 2.41 (1.23, 4.72) | 0.010 |
| Bone marrow involvement, no. (%) | 46 (14.3%) | 2.10 (1.09, 4.06) | 0.027 |
| Percent involvement, median (IQR) | 30 (10, 70) | ||
| Serum creatinine, mg/dL, median (IQR) | 0.8 (0.7, 0.9) | 1.20 (1.08, 1.33)‡ | <0.001 |
| Estimated creatinine clearance, no. (%) | |||
| < 30 mL/min | 0 (0%) | ||
| 31–60 mL/min | 26 (8.2%) | 1.85 (0.80, 4.26) | 0.15 |
| > 60 mL/min | 291 (91.8%) | Reference | |
| Hemoglobin, g/dL, median (range) | 11.5 (7–16.2) | 0.83 (0.72, 0.95) | 0.008 |
| WBC count, × 109/L, median (IQR) | 7.1 (4.8, 10) | 0.97 (0.92, 1.03) | 0.36 |
| ANC count, × 109/L, median (IQR) | 5.2 (3.2, 8) | 1.01 (0.94, 1.09) | 0.70 |
| ALC count, × 109/L, median (IQR) | 0.8 (0.5, 1.3) | 0.98 (0.95, 1.02)‡ | 0.29 |
| Aspartate aminotransferase, median (IQR) | 21 (17, 28) | 1.05 (0.97, 1.14) | 0.22 |
| Alanine aminotransferase, median (IQR) | 27 (19, 46) | 1.10 (0.96, 1.06) | 0.68 |
| Alkaline phosphatase, median (IQR) | 72 (57, 92) | 0.97 (0.91, 1.04) | 0.42 |
| Total bilirubin, median (IQR) | 0.4 (0.3, 0.6) | 1.08 (1.01, 1.16)‡ | 0.025 |
| LDH, median (IQR) | 201 (167, 264) | 1.01 (0.99, 1.02) | 0.095 |
| Albumin, mg/dL, median (IQR) | 3.8 (3.2, 4.1) | 0.93 (0.88, 0.98)‡ | 0.012 |
CI confidence interval; IQR interquartile range
†
Odds ratios for continuous variables are per 1 unit increase unless otherwise specified
‡
Per 0.1 unit increase
Per 10 unit increase
Only available in 203
Only available in 182