Table 4.

Multivariable association of patient outcome from prior MTX dose with an elevated methotrexate level at 48 h or AKI after the next MTX dose

Group based on prior MTX dose	Univariate		Multivariable*
	Odds ratio (95% CI)	p-value	Odds ratio (95% CI)	p-value
Elevated 48-h serum methotrexate concentration†
Neither HDL or AKI	Reference		Reference
HDL only	3.78 (2.46, 5.82)	<0.001	2.73 (1.72, 4.33)	<0.001
AKI only	2.19 (1.10, 4.36)	0.025	1.83 (0.91, 3.67)	0.088
Both HDL and AKI	6.29 (3.73, 10.61)	<0.001	4.36 (2.51, 7.57)	<0.001
Acute kidney injury‡
Neither HDL or AKI	Reference		Reference
HDL only	1.78 (1.07, 2.99)	0.028	1.57 (0.94, 2.63)	0.084
AKI only	3.23 (1.75, 5.97)	<0.001	2.70 (1.45, 5.02)	0.002
Both HDL and AKI	5.35 (3.20, 8.97)	<0.001	3.97 (2.29, 6.90)	<0.001

^*Adjusted for BSA, diagnosis group, SCr, hemoglobin, dose (8 vs. not), and delivered MTX dose

^†HDL only vs. both HDL and AKI: p-value = 0.056

^‡HDL only vs. both HDL and AKI: p-value<0.001; AKI only vs. both HDL and AKI: p-value = 0.28