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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Cancer Immunol Res. 2021 Apr 10;9(7):765–778. doi: 10.1158/2326-6066.CIR-20-0499

Figure 7. Exercise training sensitizes breast cancer to immune checkpoint blockade.

Figure 7.

A, Experimental design of the study. When MCa-M3C tumors reached ~100 mm3, mice underwent ExTr (60% of Vmax ExTr, for 14 days) or kept sedentary and were treated with anti-PD-1 plus anti-CTLA-4 (ICB) or isotype control IgG (i.p., every 4 days; black arrow heads). B, ICB effects on tumor volume. C, The effect of ExTr on MCa-M3C tumor growth with ICB. D–I, TCR+CD8+ T-cell infiltration and function. (D) Relative and (G) absolute numbers of CD8+ T cells. (E) Relative and (H) absolute number of granzyme B+CD8+ T cells. (F) Relative and (I) absolute number of IFNγ+CD8+ T cells with ICB and ExTr. Statistical differences by (B, D-F) one-way or (C) Two-way ANOVA, or (G-I) Kruskal-Wallis test. n=7-16 mice per group, pooled data from 2-3 independent experiments. Data presented as mean ± SEM or median ± interquartile range and distribution (violin plot, G-I).